Literature DB >> 2561055

A rapid method for in situ hybridization for viral DNA in brain biopsies from patients with AIDS.

S A Houff1, D Katz, C V Kufta, E O Major.   

Abstract

Brain biopsy is often necessary in the diagnosis of neurological complications found in AIDS patients. We describe here a rapid method of tissue preparation and in situ DNA hybridization for detecting JC virus DNA in frozen brain biopsy sections which allows the diagnosis of progressive multifocal leukoencephalopathy to be established on the day of surgery. Once the diagnosis is established, therapeutic and management decisions can be made more easily. The commercial availability of biotinylated probes for several of the DNA viruses most frequently encountered in brain infections of AIDS patients will provide wide application of these techniques to patient management.

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Year:  1989        PMID： 2561055     DOI： 10.1097/00002030-198912000-00010

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  8 in total

1.  An animal model for progressive multifocal leukoencephalopathy.

Authors:  Sheila A Haley; Walter J Atwood
Journal:  J Clin Invest       Date:  2014-11-17       Impact factor: 14.808

2.  Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures.

Authors:  Zhi-Gang Jiang; Jeffrey Cohen; Leslie J Marshall; Eugene O Major
Journal:  Antimicrob Agents Chemother       Date:  2010-09-07       Impact factor: 5.191

3.  Differentiation-specific expression from the bovine papillomavirus type 1 P2443 and late promoters.

Authors:  S K Barksdale; C C Baker
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

4.  JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency.

Authors:  M C Monaco; W J Atwood; M Gravell; C S Tornatore; E O Major
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

Review 5.  Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.

Authors:  E O Major; K Amemiya; C S Tornatore; S A Houff; J R Berger
Journal:  Clin Microbiol Rev       Date:  1992-01       Impact factor: 26.132

6.  Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients.

Authors:  Karen Yao; Susan Gagnon; Nahid Akhyani; Elizabeth Williams; Julie Fotheringham; Elliot Frohman; Olaf Stuve; Nancy Monson; Michael K Racke; Steven Jacobson
Journal:  PLoS One       Date:  2008-04-30       Impact factor: 3.240

Review 7.  Human DNA Virus Exploitation of the MAPK-ERK Cascade.

Authors:  Jeanne K DuShane; Melissa S Maginnis
Journal:  Int J Mol Sci       Date:  2019-07-12       Impact factor: 5.923

8.  Risk Assessment of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patients during 1 Year of Ocrelizumab Treatment.

Authors:  Carla Prezioso; Alfonso Grimaldi; Doriana Landi; Carolina Gabri Nicoletti; Gabriele Brazzini; Francesca Piacentini; Sara Passerini; Dolores Limongi; Marco Ciotti; Anna Teresa Palamara; Girolama Alessandra Marfia; Valeria Pietropaolo
Journal:  Viruses       Date:  2021-08-25       Impact factor: 5.048
  8 in total

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