Müfide Nuran Akçay1, Güngör Akçay2. 1. Atatürk University, Faculty of Medicine, Department of General Surgery, Erzurum, Turkey. 2. Atatürk University, Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Erzurum, Turkey.
Abstract
OBJECTIVE: Primary hyperparathyroidism (pHPT) is a disease in which the diagnosis depends increasingly on laboratory tests since the majority of patients are elderly people without typical symptoms. The aim of this study was to calculate the specificity and sensitivity rates, and positive predictive value of blood Ca, P, ALP, and iPTH levels in patients with PA. MATERIALS AND METHODS: We calculated the specificity and sensitivity rates, and positive predictive value of blood calcium (Ca), phosphorous (P), alkaline phosphatase (ALP), and intact parathormone (iPTH) levels in patients with sporadic and solitary parathyroid adenoma (PA). RESULTS: Twenty six patients with PA were included in the study. The mean age was 44.5±14.9 (18-70) years. Blood levels of Ca, P, ALP, and iPTH were 2.5±0.3 mmol/L, 0.8±0.3 mmol/L, 21.4±31.5 μkat/L, and 518.0±633.4 ng/L, respectively. With respect to the diagnosis of pHPT, the sensitivity of blood levels of iPTH, P, Ca, and ALP were 96%, 94%, 81%, and 73%, respectively. The specificity and positive predictive value of all parameters were 100% for the diagnosis of PA. CONCLUSION: Routine laboratory parameters are specific and predictive for pHPT. However, the sensitivities of P and iPTH are higher than those other parameters.
OBJECTIVE:Primary hyperparathyroidism (pHPT) is a disease in which the diagnosis depends increasingly on laboratory tests since the majority of patients are elderly people without typical symptoms. The aim of this study was to calculate the specificity and sensitivity rates, and positive predictive value of blood Ca, P, ALP, and iPTH levels in patients with PA. MATERIALS AND METHODS: We calculated the specificity and sensitivity rates, and positive predictive value of blood calcium (Ca), phosphorous (P), alkaline phosphatase (ALP), and intact parathormone (iPTH) levels in patients with sporadic and solitary parathyroid adenoma (PA). RESULTS: Twenty six patients with PA were included in the study. The mean age was 44.5±14.9 (18-70) years. Blood levels of Ca, P, ALP, and iPTH were 2.5±0.3 mmol/L, 0.8±0.3 mmol/L, 21.4±31.5 μkat/L, and 518.0±633.4 ng/L, respectively. With respect to the diagnosis of pHPT, the sensitivity of blood levels of iPTH, P, Ca, and ALP were 96%, 94%, 81%, and 73%, respectively. The specificity and positive predictive value of all parameters were 100% for the diagnosis of PA. CONCLUSION: Routine laboratory parameters are specific and predictive for pHPT. However, the sensitivities of P and iPTH are higher than those other parameters.