Suleyman Suat Okudur1, M Tahir Özer2, Sezai Demirbaş2, Murat Kalemoğlu3, Ali Harlak2, Kağan Coşkun2, Mehmet Eryılmaz4. 1. Gulhane Military Medical Academy, Haydarpasa Training Hospital, Service of General Surgery, Istanbul, Turkey. 2. Gulhane Military Medical Academy, Scholl of Military Medicine, Department of General Surgery, Ankara, Turkey. 3. Gulhane Military Medical Academy, Haydarpasa Training Hospital, Service of Emergency Medicine, Istanbul, Turkey. 4. Gulhane Military Medical Academy, Scholl of Military Medicine, Department of Emergency Medicine and Surgery, Ankara, Turkey.
Abstract
OBJECTIVE: COX-2-selective inhibitors are used in the prevention and management of colorectal carcinogenesis. Our objective was to investigate if COX-2 levels have prognostic value in patients diagnosed with colorectal carcinoma. MATERIALS AND METHODS: This is a retrospective study of 112 patients diagnosed with colorectal carcinoma between 2000-2004 from the General Surgery Department at Haydarpasa Training Hospital, Gulhane Military Medical Academy. Patients were assessed according to age, gender, localization of the tumor, stage of the tumor, remote metastasis status, patient survival, COX-2 levels and grade of differentiation. RESULTS: COX-2 levels significantly affect the duration of survival (P=0.026) and overall survival (P=0.013). The COX-2 significance value showed a tendency to change from negative to positive while a statistically meaningful decrease was observed in the survival value (r=-0.25; P=0.007) in groups related with the survival duration of cases (r=-0.24; P=0.01). The median survival was 36 (26.35-45.65) months. During the examination of survival statuses of cases, a statistically meaningful difference was determined between patients whom were alive and dead (P=0.01). CONCLUSION: We conclude that COX-2 levels are a negative predictor of survival.
OBJECTIVE:COX-2-selective inhibitors are used in the prevention and management of colorectal carcinogenesis. Our objective was to investigate if COX-2 levels have prognostic value in patients diagnosed with colorectal carcinoma. MATERIALS AND METHODS: This is a retrospective study of 112 patients diagnosed with colorectal carcinoma between 2000-2004 from the General Surgery Department at Haydarpasa Training Hospital, Gulhane Military Medical Academy. Patients were assessed according to age, gender, localization of the tumor, stage of the tumor, remote metastasis status, patient survival, COX-2 levels and grade of differentiation. RESULTS:COX-2 levels significantly affect the duration of survival (P=0.026) and overall survival (P=0.013). The COX-2 significance value showed a tendency to change from negative to positive while a statistically meaningful decrease was observed in the survival value (r=-0.25; P=0.007) in groups related with the survival duration of cases (r=-0.24; P=0.01). The median survival was 36 (26.35-45.65) months. During the examination of survival statuses of cases, a statistically meaningful difference was determined between patients whom were alive and dead (P=0.01). CONCLUSION: We conclude that COX-2 levels are a negative predictor of survival.
Authors: H Sano; Y Kawahito; R L Wilder; A Hashiramoto; S Mukai; K Asai; S Kimura; H Kato; M Kondo; T Hla Journal: Cancer Res Date: 1995-09-01 Impact factor: 12.701
Authors: J L Masferrer; B S Zweifel; P T Manning; S D Hauser; K M Leahy; W G Smith; P C Isakson; K Seibert Journal: Proc Natl Acad Sci U S A Date: 1994-04-12 Impact factor: 11.205
Authors: E Giovannucci; K M Egan; D J Hunter; M J Stampfer; G A Colditz; W C Willett; F E Speizer Journal: N Engl J Med Date: 1995-09-07 Impact factor: 91.245