Literature DB >> 25609867

Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in dengue control.

M S Mustafa1, V Rasotgi2, S Jain3, V Gupta4.   

Abstract

Dengue fever is a re-emerging public health problem with two-fifths of the world population being at risk of infection. Till now, dengue fever was believed to be caused by four different serotypes. The fifth variant DENV-5 has been isolated in October 2013. This serotype follows the sylvatic cycle unlike the other four serotypes which follow the human cycle. The likely cause of emergence of the new serotype could be genetic recombination, natural selection and genetic bottlenecks. There is no indication of the presence of DENV-5 in India. Recent clinical trials with the promising Chimerivax tetravalent vaccine suffered a setback. Discovery of DENV-5 and more such sylvatic strains in future may further impede the Dengue Vaccine Initiative. Integrated Vector Management holds the key to sustainable dengue control. Further epidemiological and ecological studies are needed to detect additional sylvatic dengue strains.

Entities:  

Keywords:  Dengue fever; Dengue vaccine; Serotype; Sylvatic

Year:  2014        PMID： 25609867      PMCID： PMC4297835          DOI： 10.1016/j.mjafi.2014.09.011

Source DB:  PubMed          Journal:  Med J Armed Forces India        ISSN： 0377-1237


  10 in total

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Review 6.  Fever from the forest: prospects for the continued emergence of sylvatic dengue virus and its impact on public health.

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Review 9.  Dengue: the risk to developed and developing countries.

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10.  Integrated vector management for malaria control in Uganda: knowledge, perceptions and policy development.

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  10 in total
  88 in total

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Review 5.  Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis.

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Authors:  Luca Cegolon; W C Heymann; John H Lange
Journal:  Singapore Med J       Date:  2018-03       Impact factor: 1.858

8.  The Global Trends and Regional Differences in Incidence of Dengue Infection from 1990 to 2019: An Analysis from the Global Burden of Disease Study 2019.

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Review 9.  Molecular studies with Aedes (Stegomyia) aegypti (Linnaeus, 1762), mosquito transmitting the dengue virus.

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