Literature DB >> 25609620

NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.

Zhitao Hu1, Amy B Vashlishan-Murray2, Joshua M Kaplan3.   

Abstract

A neuropeptide (NLP-12) and its receptor (CKR-2) potentiate tonic and evoked ACh release at Caenorhabditis elegans neuromuscular junctions. Increased evoked release is mediated by a presynaptic pathway (egl-30 Gαq and egl-8 PLCβ) that produces DAG, and by DAG binding to short and long UNC-13 proteins. Potentiation of tonic ACh release persists in mutants deficient for egl-30 Gαq and egl-8 PLCβ and requires DAG binding to UNC-13L (but not UNC-13S). Thus, NLP-12 adjusts tonic and evoked release by distinct mechanisms.
Copyright © 2015 the authors 0270-6474/15/351038-05$15.00/0.

Entities:  

Keywords:  C. elegans; CCK; Munc13; NLP-12; UNC-13; neuropeptide

Mesh：

Substances：

Year:  2015        PMID： 25609620      PMCID： PMC4300317          DOI： 10.1523/JNEUROSCI.2825-14.2015

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


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