Literature DB >> 25609025

Placebo effects on itch: a meta-analysis of clinical trials of patients with dermatological conditions.

Antoinette I M van Laarhoven1, Ineke M van der Sman-Mauriks2, A Rogier T Donders3, Mathilde C Pronk2, Peter C M van de Kerkhof4, Andrea W M Evers5.   

Abstract

Although placebo contributes to the effects of treatment for various symptoms and conditions, its effect on itch has rarely been investigated. In this meta-analysis, the magnitude of the placebo effect on itch was systematically investigated in clinical trials including patients with chronic itch due to atopic dermatitis, psoriasis, or chronic idiopathic urticaria. From searches in four databases, 34 articles were included in the quantitative analyses. Placebo treatment significantly decreased itch (1.3 out of 10, 95% confidence interval 1.02-1.61) compared with baseline itch (effect size 0.55), indicating that placebo effects have a considerable role in these patients' treatment.

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Year:  2014        PMID： 25609025     DOI： 10.1038/jid.2014.522

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  99 in total

1.  The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials.

Authors:  R W Fox; R F Lockey; S C Bukantz; D Serbousek
Journal:  J Allergy Clin Immunol       Date:  1986-12       Impact factor: 10.793

2.  Double-blind crossover trial comparing systemic chromosome-carboxylic acid with placebo in patients with atopic dermatitis.

Authors:  G Kavli; P O Larsen
Journal:  Allergy       Date:  1981-11       Impact factor: 13.146

3.  Efficacy of leukotriene receptor antagonist in chronic urticaria. A double-blind, placebo-controlled comparison of treatment with montelukast and cetirizine in patients with chronic urticaria with intolerance to food additive and/or acetylsalicylic acid.

Authors:  M L Pacor; G Di Lorenzo; R Corrocher
Journal:  Clin Exp Allergy       Date:  2001-10       Impact factor: 5.018

4.  Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch.

Authors:  Miwa Hosogi; Martin Schmelz; Yoshiki Miyachi; Akihiko Ikoma
Journal:  Pain       Date:  2006-07-13       Impact factor: 6.961

5.  The relationship between pruritus and the clinical signs of psoriasis in patients receiving tofacitinib.

Authors:  Andrew G Bushmakin; Carla Mamolo; Joseph C Cappelleri; Michelle Stewart
Journal:  J Dermatolog Treat       Date:  2013-12-02       Impact factor: 3.359

6.  Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies.

Authors:  Lawrence F Eichenfield; Wynnis L Tom; Timothy G Berger; Alfons Krol; Amy S Paller; Kathryn Schwarzenberger; James N Bergman; Sarah L Chamlin; David E Cohen; Kevin D Cooper; Kelly M Cordoro; Dawn M Davis; Steven R Feldman; Jon M Hanifin; David J Margolis; Robert A Silverman; Eric L Simpson; Hywel C Williams; Craig A Elmets; Julie Block; Christopher G Harrod; Wendy Smith Begolka; Robert Sidbury
Journal:  J Am Acad Dermatol       Date:  2014-05-09       Impact factor: 11.527

Review 7.  Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment.

Authors:  A Hróbjartsson; P C Gøtzsche
Journal:  J Intern Med       Date:  2004-08       Impact factor: 8.989

8.  Guidelines of care for the management of psoriasis and psoriatic arthritis: section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents.

Authors:  Alan Menter; Neil J Korman; Craig A Elmets; Steven R Feldman; Joel M Gelfand; Kenneth B Gordon; Alice B Gottlieb; John Y M Koo; Mark Lebwohl; Henry W Lim; Abby S Van Voorhees; Karl R Beutner; Reva Bhushan
Journal:  J Am Acad Dermatol       Date:  2009-06-03       Impact factor: 11.527

9.  Efficacy of leukotriene receptor antagonist with an anti-H1 receptor antagonist for treatment of chronic idiopathic urticaria.

Authors:  Kong-Sang Wan
Journal:  J Dermatolog Treat       Date:  2009       Impact factor: 3.359

10.  Oxatomide in the treatment of chronic urticaria. A double-blind placebo-controlled trial.

Authors:  W Peremans; R L Mertens; J Morias; H Campaert
Journal:  Dermatologica       Date:  1981
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  25 in total

Review 1.  [Placebo and nocebo effects on itch : Methodological and clinical implications].

Authors:  J Tekampe; K J Peerdeman; D J P Bartels; A I M van Laarhoven; A W M Evers
Journal:  Hautarzt       Date:  2018-08       Impact factor: 0.751

Review 2.  [Placebo response - Mechanisms and clinical applications].

Authors:  A Sölle; M Worm; H Flor; R Klinger
Journal:  Schmerz       Date:  2016-10       Impact factor: 1.107

Review 3.  Practice Gaps in Pruritus.

Authors:  Jonathan I Silverberg
Journal:  Dermatol Clin       Date:  2016-07       Impact factor: 3.478

Review 4.  Diagnosis and treatment of pruritus.

Authors:  Dominik A Nowak; Jensen Yeung
Journal:  Can Fam Physician       Date:  2017-12       Impact factor: 3.275

Review 5. 

Authors:  Dominik Nowak; Jensen Yeung
Journal:  Can Fam Physician       Date:  2017-12       Impact factor: 3.275

6.  Acupuncture for the Treatment of Itch: Literature Review and Future Perspectives.

Authors:  Kevin Yun Kim; Jessica Shen Tsy Wu Kim; André Wan Wen Tsai; Wu Tu Hsing
Journal:  Med Acupunct       Date:  2021-04-19

Review 7.  [The effect of treatment expectations on pruritus and skin pain].

Authors:  F Krefting; S Hölsken; M Schedlowski; W Sondermann
Journal:  Schmerz       Date:  2021-10-27       Impact factor: 1.629

8.  Minimizing nocebo effects by conditioning with verbal suggestion: A randomized clinical trial in healthy humans.

Authors:  Danielle J P Bartels; Antoinette I M van Laarhoven; Michiel Stroo; Kim Hijne; Kaya J Peerdeman; A Rogier T Donders; Peter C M van de Kerkhof; Andrea W M Evers
Journal:  PLoS One       Date:  2017-09-14       Impact factor: 3.240

9.  The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin.

Authors:  Yutaka Takagi; Xuanhe Ning; Akihiko Takahashi; Chiaki Ishizaki; Takahiro Nishizaka; Kazuhiro Kaizu; Masahiro Miyaki; Hotaka Yamamuro; Makoto Kawashima
Journal:  Clin Cosmet Investig Dermatol       Date:  2018-04-06

10.  Anti-pruritic effect of nemolizumab in hemodialysis patients with uremic pruritus: a phase II, randomized, double-blind, placebo-controlled clinical study.

Authors:  Eriko Kinugasa; Ken Igawa; Hisaki Shimada; Morihiro Kondo; Satoshi Funakoshi; Naoki Imada; Noritomo Itami; Naoki Fukazawa; Ryoko Takubo; Yuichi Kawata; Hiroyuki Murota
Journal:  Clin Exp Nephrol       Date:  2021-03-22       Impact factor: 2.801
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