Literature DB >> 25608936

A systems approach to drug discovery in Alzheimer's disease.

Michael Shelanski1, William Shin, Soline Aubry, Peter Sims, Mariano J Alvarez, Andrea Califano.   

Abstract

In the articles included in this volume, one feels a strong frustration among the writers with the slow course of therapeutics development for Alzheimer's disease and with the clinical failure of targeted therapeutic agents despite substantial progress in our understanding of the biology and biochemistry of the disease.

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Year:  2015        PMID： 25608936      PMCID： PMC4322083          DOI： 10.1007/s13311-014-0335-5

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


  53 in total

1.  Causal protein-signaling networks derived from multiparameter single-cell data.

Authors:  Karen Sachs; Omar Perez; Dana Pe'er; Douglas A Lauffenburger; Garry P Nolan
Journal:  Science       Date:  2005-04-22       Impact factor: 47.728

2.  NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.

Authors:  Teresa Palomero; Wei Keat Lim; Duncan T Odom; Maria Luisa Sulis; Pedro J Real; Adam Margolin; Kelly C Barnes; Jennifer O'Neil; Donna Neuberg; Andrew P Weng; Jon C Aster; Francois Sigaux; Jean Soulier; A Thomas Look; Richard A Young; Andrea Califano; Adolfo A Ferrando
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-17       Impact factor: 11.205

3.  Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.

Authors:  Brikha R Shrestha; Ottavio V Vitolo; Powrnima Joshi; Tamar Lordkipanidze; Michael Shelanski; Anna Dunaevsky
Journal:  Mol Cell Neurosci       Date:  2006-09-08       Impact factor: 4.314

4.  Reverse engineering cellular networks.

Authors:  Adam A Margolin; Kai Wang; Wei Keat Lim; Manjunath Kustagi; Ilya Nemenman; Andrea Califano
Journal:  Nat Protoc       Date:  2006       Impact factor: 13.491

5.  Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.

Authors:  Bing Gong; Zixuan Cao; Ping Zheng; Ottavio V Vitolo; Shumin Liu; Agnieszka Staniszewski; Donna Moolman; Hong Zhang; Michael Shelanski; Ottavio Arancio
Journal:  Cell       Date:  2006-08-25       Impact factor: 41.582

6.  Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.

Authors:  Winnie S Liang; Travis Dunckley; Thomas G Beach; Andrew Grover; Diego Mastroeni; Douglas G Walker; Richard J Caselli; Walter A Kukull; Daniel McKeel; John C Morris; Christine Hulette; Donald Schmechel; Gene E Alexander; Eric M Reiman; Joseph Rogers; Dietrich A Stephan
Journal:  Physiol Genomics       Date:  2006-10-31       Impact factor: 3.107

7.  Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

Authors:  Cathy Andorfer; Yvonne Kress; Marisol Espinoza; Rohan de Silva; Kerry L Tucker; Yves-Alain Barde; Karen Duff; Peter Davies
Journal:  J Neurochem       Date:  2003-08       Impact factor: 5.372

8.  Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

Authors:  Winnie S Liang; Travis Dunckley; Thomas G Beach; Andrew Grover; Diego Mastroeni; Keri Ramsey; Richard J Caselli; Walter A Kukull; Daniel McKeel; John C Morris; Christine M Hulette; Donald Schmechel; Eric M Reiman; Joseph Rogers; Dietrich A Stephan
Journal:  Physiol Genomics       Date:  2008-02-12       Impact factor: 3.107

9.  ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context.

Authors:  Adam A Margolin; Ilya Nemenman; Katia Basso; Chris Wiggins; Gustavo Stolovitzky; Riccardo Dalla Favera; Andrea Califano
Journal:  BMC Bioinformatics       Date:  2006-03-20       Impact factor: 3.169

10.  A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas.

Authors:  Kartik M Mani; Celine Lefebvre; Kai Wang; Wei Keat Lim; Katia Basso; Riccardo Dalla-Favera; Andrea Califano
Journal:  Mol Syst Biol       Date:  2008-02-12       Impact factor: 11.429
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  4 in total

Review 1.  The recurrent architecture of tumour initiation, progression and drug sensitivity.

Authors:  Andrea Califano; Mariano J Alvarez
Journal:  Nat Rev Cancer       Date:  2016-12-15       Impact factor: 60.716

2.  Master regulators of infiltrate recruitment in autoimmune disease identified through network-based molecular deconvolution.

Authors:  James C Chen; Jane E Cerise; Ali Jabbari; Raphael Clynes; Angela M Christiano
Journal:  Cell Syst       Date:  2015-11-25       Impact factor: 10.304

Review 3.  A systems biology approach to discovering pathway signaling dysregulation in metastasis.

Authors:  Robert Clarke; Pavel Kraikivski; Brandon C Jones; Catherine M Sevigny; Surojeet Sengupta; Yue Wang
Journal:  Cancer Metastasis Rev       Date:  2020-08-10       Impact factor: 9.264

Review 4.  The Coming of Age of the Angiotensin Hypothesis in Alzheimer's Disease: Progress Toward Disease Prevention and Treatment?

Authors:  Patrick Gavin Kehoe
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472
  4 in total

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