Literature DB >> 25608860

Cerebrovascular and mitochondrial abnormalities in Alzheimer's disease: a brief overview.

Cristina Carvalho1, Sónia C Correia1,2, George Perry3,4, Rudy J Castellani5, Paula I Moreira6,7.   

Abstract

Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer's disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.

Entities:  

Keywords:  Alzheimer’s disease; Brain vasculature; Mitochondria; Oxidative stress

Mesh：

Year:  2015        PMID： 25608860     DOI： 10.1007/s00702-015-1367-7

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  52 in total

1.  Brain cytochrome oxidase in Alzheimer's disease.

Authors:  S J Kish; C Bergeron; A Rajput; S Dozic; F Mastrogiacomo; L J Chang; J M Wilson; L M DiStefano; J N Nobrega
Journal:  J Neurochem       Date:  1992-08       Impact factor: 5.372

Review 2.  Alzheimer's disease.

Authors:  Henry W Querfurth; Frank M LaFerla
Journal:  N Engl J Med       Date:  2010-01-28       Impact factor: 91.245

3.  Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients.

Authors:  L Claudio
Journal:  Acta Neuropathol       Date:  1996       Impact factor: 17.088

4.  Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes.

Authors:  Cristina Carvalho; Maria S Santos; Inês Baldeiras; Catarina R Oliveira; Raquel Seiça; Paula I Moreira
Journal:  Curr Neurovasc Res       Date:  2010-11       Impact factor: 1.990

Review 5.  Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies.

Authors:  Behnam Sabayan; Steffy Jansen; Anna M Oleksik; Matthias J P van Osch; Mark A van Buchem; Peter van Vliet; Anton J M de Craen; Rudi G J Westendorp
Journal:  Ageing Res Rev       Date:  2011-12-27       Impact factor: 10.895

6.  Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.

Authors:  Kristina Leuner; Tanja Schütt; Christopher Kurz; Schamim H Eckert; Carola Schiller; Angelo Occhipinti; Sören Mai; Marina Jendrach; Gunter P Eckert; Shane E Kruse; Richard D Palmiter; Ulrich Brandt; Stephan Dröse; Ilka Wittig; Michael Willem; Christian Haass; Andreas S Reichert; Walter E Müller
Journal:  Antioxid Redox Signal       Date:  2012-02-28       Impact factor: 8.401

7.  Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells.

Authors:  Huai-Chia Chang; Tyng-Guey Chen; Yu-Ting Tai; Ta-Liang Chen; Wen-Ta Chiu; Ruei-Ming Chen
Journal:  J Cereb Blood Flow Metab       Date:  2010-10-13       Impact factor: 6.200

8.  Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.

Authors:  Hsueh-Meei Huang; Hsiu-Chong Ou; Hui Xu; Huan-Lian Chen; Corinne Fowler; Gary E Gibson
Journal:  J Neurosci Res       Date:  2003-10-15       Impact factor: 4.164

Review 9.  Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia.

Authors:  Cristina Carvalho; Sónia C Correia; Renato X Santos; Susana Cardoso; Paula I Moreira; Timothy A Clark; Xiongwei Zhu; Mark A Smith; George Perry
Journal:  J Bioenerg Biomembr       Date:  2009-10       Impact factor: 2.945

10.  S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.

Authors:  Dong-Hyung Cho; Tomohiro Nakamura; Jianguo Fang; Piotr Cieplak; Adam Godzik; Zezong Gu; Stuart A Lipton
Journal:  Science       Date:  2009-04-03       Impact factor: 47.728
View more
  6 in total

1.  A derangement of the brain wound healing process may cause some cases of Alzheimer's disease.

Authors:  Steven Lehrer; Peter H Rheinstein
Journal:  Discov Med       Date:  2016-08       Impact factor: 2.970

2.  Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer's Disease.

Authors:  Isaura V A Martins; Jack Rivers-Auty; Stuart M Allan; Catherine B Lawrence
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

3.  Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.

Authors:  Amit U Joshi; Nay L Saw; Mehrdad Shamloo; Daria Mochly-Rosen
Journal:  Oncotarget       Date:  2017-12-22

Review 4.  Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.

Authors:  Judite R M Coimbra; Daniela F F Marques; Salete J Baptista; Cláudia M F Pereira; Paula I Moreira; Teresa C P Dinis; Armanda E Santos; Jorge A R Salvador
Journal:  Front Chem       Date:  2018-05-24       Impact factor: 5.221

5.  Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density.

Authors:  Emsehgol Nikmahzar; Mehrdad Jahanshahi; Leila Elyasi; Mohsen Saeidi; Fatemeh Babakordi; Gozal Bahlakeh
Journal:  Iran J Basic Med Sci       Date:  2019-02       Impact factor: 2.699

6.  TGR5 Activation Ameliorates Mitochondrial Homeostasis via Regulating the PKCδ/Drp1-HK2 Signaling in Diabetic Retinopathy.

Authors:  Meng-Yuan Zhang; Lingpeng Zhu; Xinhua Zheng; Tian-Hua Xie; Wenjuan Wang; Jian Zou; Yan Li; Hong-Ying Li; Jiping Cai; Shun Gu; Yong Yao; Ting-Ting Wei
Journal:  Front Cell Dev Biol       Date:  2022-01-14
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.