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Literature DB >> 2560818

Effect of naftidrofuryl on metabolism and survival of cultured neurons.

Abstract

The direct influence of Naftidrofuryl, a drug widely used for the treatment of cerebrovascular diseases, on the metabolism and survival of neurons was investigated in 8-day-old chick embryo forebrain cultures. Interaction of Naftidrofuryl with neurons resulted in the increase of the intracellular cyclic AMP levels. Naftidrofuryl stimulated deoxyglucose uptake and lactate production in a time- and dose-dependent fashion. These effects were observed after a few minutes following the beginning of the treatment with Naftidrofuryl. In parallel to the action on the metabolic activities, Naftidrofuryl was able to increase the survival rate of a significant proportion of the neuronal population. These data support the notion that Naftidrofuryl may act as a neuroprotective agent.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2560818 DOI： 10.1007/BF00965509

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

29 in total

1. Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures.

Authors: L Hertz; J Drejer; A Schousboe
Journal: Neurochem Res Date: 1988-07 Impact factor: 3.996

2. Effects of naftidrofuryl on adrenergic nerves, endothelium and smooth muscle in isolated canine blood vessels.

Authors: J F Zander; L L Aarhus; Z S Katusic; G M Rubanyi; P M Vanhoutte
Journal: J Pharmacol Exp Ther Date: 1986-12 Impact factor: 4.030

3. Developmental changes in cultured neurones from chick embryo cerebral hemispheres. An ultrastructural and neurochemical study.

Authors: J C Louis; B Pettmann; J Courageot; J F Rumigny; P Mandel; M Sensenbrenner
Journal: Exp Brain Res Date: 1981 Impact factor: 1.972

4. Cerebral blood flow regulation. II. Vasodilator mechanisms.

Authors: L L Levy; J D Wallace
Journal: Stroke Date: 1977 Mar-Apr Impact factor: 7.914

Review 5. Role of endothelium in responses of vascular smooth muscle.

Authors: R F Furchgott
Journal: Circ Res Date: 1983-11 Impact factor: 17.367

6. The effect of naftidrofuryl on cyanide-induced hypoxic damage to glucose and energy metabolism in brain cortex of rats.

Authors: S Hoyer
Journal: Arzneimittelforschung Date: 1984

10. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

Authors: K Suzuki; T Kono
Journal: Proc Natl Acad Sci U S A Date: 1980-05 Impact factor: 11.205

3 in total

1. Postischemic breakdown in hippocampal protein synthesis and mnesic deficits in rats: pharmacological improvement by curative naftidrofuryl treatment.

Authors: Y Lamproglou; M Le Poncin; W Jacques; N Wiernsperger; J R Rapin
Journal: Metab Brain Dis Date: 1992-12 Impact factor: 3.584

Review 2. Oral naftidrofuryl. A review of its pharmacology and therapeutic use in the management of peripheral occlusive arterial disease.

Authors: L B Barradell; R N Brogden
Journal: Drugs Aging Date: 1996-04 Impact factor: 3.923

Review 3. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs.

Authors: Matěj Malík; Pavel Tlustoš
Journal: Nutrients Date: 2022-08-17 Impact factor: 6.706