Literature DB >> 25606203

"I Am Hot, Irritable and Feeling Low; What Alternatives do I have Besides Hormone Replacement Therapy?".

A S Sulaiha1, I Nazimah1, Z Zainurrashid2.   

Abstract

Women at the end of their reproductive age often complain of climacteric symptoms which can be quite debilitating at times. Physiological changes due to deficient oestrogen have received global attention in the search for an acceptable and safe measure to improve quality of life for women with these complaints. Hormone replacement therapy (HRT) used to be the main treatment for menopausal symptoms. Lately there are concerns about its possible adverse effects of increasing risks of breast malignancy, heart diseases, etc. Complementary Alternative Medicine (CAM) plays a significant role in relieving these climacteric symptoms especially in women with contraindications to hormonal therapy and in those who are worried of its adverse effects. It is important for women to be aware of these CAM to provide them with options to improve their quality of life. This paper explores other pharmacological and non-pharmacological measures as alternatives to hormone replacement therapy (HRT), to assess how useful and reliable they are according to available scientific evidence.

Entities:  

Keywords:  Menopausal symptoms; complementary therapy; hormone replacement therapy; lifestyle changes; pharmacological therapy

Year:  2010        PMID: 25606203      PMCID: PMC4170410     

Source DB:  PubMed          Journal:  Malays Fam Physician        ISSN: 1985-2274


  30 in total

Review 1.  Oral oestrogen replacement therapy versus placebo for hot flushes.

Authors:  A MacLennan; S Lester; V Moore
Journal:  Cochrane Database Syst Rev       Date:  2001

2.  Dietary phyto-oestrogens and the menopause in Japan.

Authors:  H Adlercreutz; E Hämäläinen; S Gorbach; B Goldin
Journal:  Lancet       Date:  1992-05-16       Impact factor: 79.321

Review 3.  Alternative and complementary therapies for the menopause.

Authors:  Francesca Borrelli; Edzard Ernst
Journal:  Maturitas       Date:  2010-06-30       Impact factor: 4.342

Review 4.  The clinical platform for the 17beta-estradiol vaginal releasing ring.

Authors:  G A Bachmann
Journal:  Am J Obstet Gynecol       Date:  1998-05       Impact factor: 8.661

Review 5.  Hormone replacement therapy and cognition: systematic review and meta-analysis.

Authors:  E S LeBlanc; J Janowsky; B K Chan; H D Nelson
Journal:  JAMA       Date:  2001-03-21       Impact factor: 56.272

6.  The effects of relaxation response training on menopausal symptoms.

Authors:  J H Irvin; A D Domar; C Clark; P C Zuttermeister; R Friedman
Journal:  J Psychosom Obstet Gynaecol       Date:  1996-12       Impact factor: 2.949

7.  Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group.

Authors:  I K Wiklund; L A Mattsson; R Lindgren; C Limoni
Journal:  Int J Clin Pharmacol Res       Date:  1999

8.  Management of postmenopausal hot flushes with venlafaxine hydrochloride: a randomized, controlled trial.

Authors:  Michele L Evans; Elizabeth Pritts; Eric Vittinghoff; Karen McClish; Kevin S Morgan; Robert B Jaffe
Journal:  Obstet Gynecol       Date:  2005-01       Impact factor: 7.661

9.  Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausal women: an analysis of two prospective, parallel, randomized studies.

Authors:  E Zaborowska; J Brynhildsen; S Damberg; M Fredriksson; L Lindh-Astrand; E Nedstrand; Y Wyon; M Hammar
Journal:  Climacteric       Date:  2007-02       Impact factor: 3.005

10.  Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study.

Authors:  Sally A Shumaker; Claudine Legault; Lewis Kuller; Stephen R Rapp; Leon Thal; Dorothy S Lane; Howard Fillit; Marcia L Stefanick; Susan L Hendrix; Cora E Lewis; Kamal Masaki; Laura H Coker
Journal:  JAMA       Date:  2004-06-23       Impact factor: 56.272

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