Literature DB >> 25605442

Cytotoxic activity and protein binding through an unusual oxidative mechanism by an iridium(I)-NHC complex.

Y Gothe1, T Marzo, L Messori, N Metzler-Nolte.   

Abstract

A new NHC iridium(I) complex (1) showing significant antiproliferative properties in vitro is described here. Its crystal structure, solution behaviour and interactions with the model proteins cytochrome c (cyt c) and lysozyme were investigated. High resolution ESI-MS measurements suggest that this iridium(i) complex acts as a prodrug and binds cyt c tightly through an unusual "oxidative" mechanism. Eventually, an iridium(III)-NHC fragment is found associated to the protein.

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Year:  2015        PMID： 25605442     DOI： 10.1039/c4cc10014j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Bioactivity and Development of Small Non-Platinum Metal-Based Chemotherapeutics.

Authors:  Maria Grazia Ferraro; Marialuisa Piccolo; Gabriella Misso; Rita Santamaria; Carlo Irace
Journal:  Pharmaceutics       Date:  2022-04-28       Impact factor: 6.525

2.  Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes.

Authors:  Marcelo Echeverri; Amparo Alvarez-Valdés; Francisco Navas; Josefina Perles; Isabel Sánchez-Pérez; A G Quiroga
Journal:  R Soc Open Sci       Date:  2018-02-21       Impact factor: 2.963

3.  Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity.

Authors:  Lihua Lu; Li-juan Liu; Wei-chieh Chao; Hai-Jing Zhong; Modi Wang; Xiu-Ping Chen; Jin-Jian Lu; Ruei-nian Li; Dik-Lung Ma; Chung-Hang Leung
Journal:  Sci Rep       Date:  2015-09-29       Impact factor: 4.379
  3 in total

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