Literature DB >> 25605361

In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.

Stefano Mancini1, Frédéric Laurent2, Tiago R Veloso1, Marlyse Giddey1, Jacques Vouillamoz1, François Vandenesch2, Philippe Moreillon1, José M Entenza3.   

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These results suggest that mecC-MRSA infections may successfully respond to treatment with β-lactams.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25605361      PMCID： PMC4356768          DOI： 10.1128/AAC.04733-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  32 in total

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4.  Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary.

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Review 5.  Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications.

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6.  Effect of temperature on the in vitro susceptibility of Staphylococcus aureus to penicillinase-resistant penicillins.

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Journal:  Lancet Infect Dis       Date:  2011-08       Impact factor: 25.071
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  2 in total

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2.  Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections.

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