Literature DB >> 25604652

The future of research in female pelvic medicine.

Jamie Chao1, Toby C Chai.   

Abstract

Female pelvic medicine and reconstructive surgery (FPMRS) was recently recognized as a subspecialty by the American Board of Medical Specialties (ABMS). FPMRS treats female pelvic disorders (FPD) including pelvic organ prolapse (POP), urinary incontinence (UI), fecal incontinence (FI), lower urinary tract symptoms (LUTS), lower urinary tract infections (UTI), pelvic pain, and female sexual dysfunction (FSD). These conditions affect large numbers of individuals, resulting in significant patient, societal, medical, and financial burdens. Given that treatments utilize both medical and surgical approaches, areas of research in FPD necessarily cover a gamut of topics, ranging from mechanistically driven basic science research to randomized controlled trials. While basic science research is slow to impact clinical care, transformational changes in a field occur through basic investigations. On the other hand, clinical research yields incremental changes to clinical care. Basic research intends to change understanding whereas clinical research intends to change practice. However, the best approach is to incorporate both basic and clinical research into a translational program which makes new discoveries and effects positive changes to clinical practice. This review examines current research in FPD, with focus on translational potential, and ponders the future of FPD research. With a goal of improving the care and outcomes in patients with FPD, a strategic collaboration of stakeholders (patients, advocacy groups, physicians, researchers, professional medical associations, legislators, governmental biomedical research agencies, pharmaceutical companies, and medical device companies) is an absolute requirement in order to generate funding needed for FPD translational research.

Entities:  

Mesh:

Year:  2015        PMID: 25604652     DOI: 10.1007/s11934-014-0474-6

Source DB:  PubMed          Journal:  Curr Urol Rep        ISSN: 1527-2737            Impact factor:   3.092


  79 in total

1.  Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo.

Authors:  Wei Yang; Yongsoo Kim; Taek-Kyun Kim; Susan K Keay; Kwang Pyo Kim; Hanno Steen; Michael R Freeman; Daehee Hwang; Jayoung Kim
Journal:  BJU Int       Date:  2012-06-28       Impact factor: 5.588

2.  The path to personalized medicine.

Authors:  Margaret A Hamburg; Francis S Collins
Journal:  N Engl J Med       Date:  2010-06-15       Impact factor: 91.245

3.  Comparison of leak point pressure methods in an animal model of stress urinary incontinence.

Authors:  Deirdre A Conway; Izumi Kamo; Naoki Yoshimura; Michael B Chancellor; Tracy W Cannon
Journal:  Int Urogynecol J Pelvic Floor Dysfunct       Date:  2005-08-19

4.  First FDA authorization for next-generation sequencer.

Authors:  Francis S Collins; Margaret A Hamburg
Journal:  N Engl J Med       Date:  2013-11-19       Impact factor: 91.245

5.  Proteomic analysis related to stress urinary incontinence following vaginal trauma in female mice.

Authors:  Huey-Yi Chen; Chao-Jung Chen; Yu-Ning Lin; Yung-Hsiang Chen; Wen-Chi Chen; Chuan-Mu Chen
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2013-08-29       Impact factor: 2.435

6.  Lancet withdraws research paper and warns authors about rules of "gift authorship".

Authors:  Clare Dyer
Journal:  BMJ       Date:  2008-09-17

7.  The rhesus macaque as an animal model for pelvic organ prolapse.

Authors:  Lesley N Otto; Ov D Slayden; Amanda L Clark; Robert M Brenner
Journal:  Am J Obstet Gynecol       Date:  2002-03       Impact factor: 8.661

8.  A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders.

Authors:  Michael A Pezzone; Ruomei Liang; Matthew O Fraser
Journal:  Gastroenterology       Date:  2005-06       Impact factor: 22.682

9.  Fibulin-5 (FBLN5) gene polymorphism is associated with pelvic organ prolapse.

Authors:  Maryam B Khadzhieva; Svetlana V Kamoeva; Anastasya G Chumachenko; Anastasya V Ivanova; Ilya V Volodin; Ivan S Vladimirov; Serikbay K Abilev; Lyubov E Salnikova
Journal:  Maturitas       Date:  2014-05-13       Impact factor: 4.342

10.  Abnormal immunological profile and vaginal microbiota in women prone to urinary tract infections.

Authors:  Pirkka V Kirjavainen; Stephen Pautler; Miren L Baroja; Kingsley Anukam; Kate Crowley; Kristine Carter; Gregor Reid
Journal:  Clin Vaccine Immunol       Date:  2008-11-19
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