Muhammad Akram1, Nabila Roohi2. 1. Department of Physiology, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur, AJK. 2. Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore.
Abstract
OBJECTIVE: To systematically examine the hormonal variations and their interactions in a local cohort of PCOS patients. STUDY DESIGN: A cross-sectional, analytical study. PLACE AND DURATION OF STUDY: King Edward Medical University and associated Mayo Hospital, Lahore, Pakistan, from June 2009 to May 2010. METHODOLOGY: The study comprised of 50 controls, 65 PCOS patients and 25 First Degree Relatives (FDRs) of patients, aged 18 - 45 years. Clinical examination, findings, detailed menstrual and family history was recorded through a comprehensive questionnaire followed by ovarian ultrasound examination. The blood samples were drawn for hormonal analysis by radioimmunoassay and immunoradiometric assay. RESULTS: Body mass index, Luteinizing Hormone (LH), LH:FSH ratio, insulin, testosterone, androstenedione and prolactin were significantly elevated in PCOS patients compared to control group. The FDRs of patients did not indicate significant variations when compared to control. LH and androstenedione were found to be significantly correlated. CONCLUSION: The gonadotrophins, LH to FSH ratio and androgens are dependable diagnostic parameters of PCOS. LH appears to be the most important in this regard, leading to hyperandrogenism.
OBJECTIVE: To systematically examine the hormonal variations and their interactions in a local cohort of PCOSpatients. STUDY DESIGN: A cross-sectional, analytical study. PLACE AND DURATION OF STUDY: King Edward Medical University and associated Mayo Hospital, Lahore, Pakistan, from June 2009 to May 2010. METHODOLOGY: The study comprised of 50 controls, 65 PCOSpatients and 25 First Degree Relatives (FDRs) of patients, aged 18 - 45 years. Clinical examination, findings, detailed menstrual and family history was recorded through a comprehensive questionnaire followed by ovarian ultrasound examination. The blood samples were drawn for hormonal analysis by radioimmunoassay and immunoradiometric assay. RESULTS: Body mass index, Luteinizing Hormone (LH), LH:FSH ratio, insulin, testosterone, androstenedione and prolactin were significantly elevated in PCOSpatients compared to control group. The FDRs of patients did not indicate significant variations when compared to control. LH and androstenedione were found to be significantly correlated. CONCLUSION: The gonadotrophins, LH to FSH ratio and androgens are dependable diagnostic parameters of PCOS. LH appears to be the most important in this regard, leading to hyperandrogenism.
Authors: Enrico Carmina; Brigitte Dreno; W Anne Lucky; W George Agak; Anuja Dokras; Jin Ju Kim; Rogerio A Lobo; Fahimeh Ramezani Tehrani; Daniel Dumesic Journal: J Endocr Soc Date: 2022-02-06
Authors: Himani Nautiyal; Syed Sarim Imam; Sultan Alshehri; Mohammed M Ghoneim; Muhammad Afzal; Sami I Alzarea; Emine Güven; Fahad A Al-Abbasi; Imran Kazmi Journal: Biomedicines Date: 2022-02-24