Literature DB >> 25603354

Engagement of DYRK2 in proper control for cell division.

Naoe Taira Nihira1, Kiyotsugu Yoshida.   

Abstract

Dysregulation of cell cycle machinery causes abnormal cell division, leading to cancer development. To drive cell cycle properly, expression levels of cell cycle regulators are tightly regulated through the cell cycle. Dual specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) is a Ser/Thr kinase, and its intracellular functions had not been elucidated for decades. Recent studies have shown that DYRK2 down-regulates key molecules on cell cycle control. This review mainly highlights the DYRK2 function during cell division. In addition, we summarize tumor suppressive role of DYRK2 in cancer cells and discuss future research directions for DYRK2 toward the novel cancer therapies.

Entities:  

Keywords:  DYRK2; EMT; apoptosis; cell cycle regulation; proteasomal degradation

Mesh：

Substances：

Year:  2015        PMID： 25603354      PMCID： PMC4613861          DOI： 10.1080/15384101.2015.1007751

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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