Roy W R Dudley1, Michelle R Torok, Danielle R Gallegos, Jean M Mulcahy-Levy, Lindsey M Hoffman, Arthur K Liu, Michael H Handler, Todd C Hankinson. 1. *Pediatric Neurosurgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ‡Children's Outcomes Research Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado; §Division of Neuro-oncology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ¶Department of Radiation Oncology, University of Colorado Anschutz Medical Campus, Anschutz Cancer Pavilion, Aurora, Colorado.
Abstract
BACKGROUND: Low-grade gangliogliomas/gangliocytomas (GGs) are rare tumors of the central nervous system that occur mostly in young people. Because of their rarity, large-scale, population-based studies focusing on epidemiology and outcomes are lacking. OBJECTIVE: To use the Surveillance, Epidemiology, and End Results (SEER) data sets of the National Cancer Institute to study demographics, tumor location, initial treatment, and outcome data on low-grade GGs in children. METHODS: SEER-STAT v8.1.2 identified all patients aged 0 to 19 years in the SEER data sets with low-grade GGs. Using the Kaplan-Meier method and Cox proportional hazard regression, we examined associations between these characteristics and survival. RESULTS: There were 348 children with low-grade GGs diagnosed from 2004 to 2010, with a median follow-up of 37 months. Tumors were more prevalent in males (n = 208, 59.8%) than females (n = 140, 40.2%) (P < .001). Almost 63% occurred in children >10 years, whereas only 3.5% were found in those <1 year old. Approximately 50% were located in the temporal lobes, and only 3.7% and 3.5% were located in the brainstem and spinal cord, respectively. Surgery was performed on 91.6% of cases, with gross total resection achieved in 68.3%. Radiation was used in 3.2%. Young age (<1 year) and brainstem location were associated with worse overall survival. CONCLUSION: This study shows that low-grade GGs occur in older children with a male preference. Gross total resection is achieved in the majority of cases, and radiation is rarely used. Although the majority of patients have an excellent prognosis, infants and patients with brainstem tumors have worse survival rates.
BACKGROUND: Low-grade gangliogliomas/gangliocytomas (GGs) are rare tumors of the central nervous system that occur mostly in young people. Because of their rarity, large-scale, population-based studies focusing on epidemiology and outcomes are lacking. OBJECTIVE: To use the Surveillance, Epidemiology, and End Results (SEER) data sets of the National Cancer Institute to study demographics, tumor location, initial treatment, and outcome data on low-grade GGs in children. METHODS: SEER-STAT v8.1.2 identified all patients aged 0 to 19 years in the SEER data sets with low-grade GGs. Using the Kaplan-Meier method and Cox proportional hazard regression, we examined associations between these characteristics and survival. RESULTS: There were 348 children with low-grade GGs diagnosed from 2004 to 2010, with a median follow-up of 37 months. Tumors were more prevalent in males (n = 208, 59.8%) than females (n = 140, 40.2%) (P < .001). Almost 63% occurred in children >10 years, whereas only 3.5% were found in those <1 year old. Approximately 50% were located in the temporal lobes, and only 3.7% and 3.5% were located in the brainstem and spinal cord, respectively. Surgery was performed on 91.6% of cases, with gross total resection achieved in 68.3%. Radiation was used in 3.2%. Young age (<1 year) and brainstem location were associated with worse overall survival. CONCLUSION: This study shows that low-grade GGs occur in older children with a male preference. Gross total resection is achieved in the majority of cases, and radiation is rarely used. Although the majority of patients have an excellent prognosis, infants and patients with brainstem tumors have worse survival rates.
Authors: Abraham Noorbakhsh; Jessica A Tang; Logan P Marcus; Brandon McCutcheon; David D Gonda; Craig S Schallhorn; Mark A Talamini; David C Chang; Bob S Carter; Clark C Chen Journal: J Neurosurg Date: 2013-11-08 Impact factor: 5.115
Authors: Andrew M Donson; Bette K Kleinschmidt-DeMasters; Dara L Aisner; Lynne T Bemis; Diane K Birks; Jean M Mulcahy Levy; Amy A Smith; Michael H Handler; Nicholas K Foreman; Sarah Z Rush Journal: Brain Pathol Date: 2013-12-23 Impact factor: 6.508
Authors: Todd C Hankinson; Emma C Fields; Michelle R Torok; Brenda L Beaty; Michael H Handler; Nicholas K Foreman; Brent R O'neill; Arthur K Liu Journal: J Neurooncol Date: 2012-08-23 Impact factor: 4.130
Authors: Julia J Compton; Nadia N Issa Laack; Laurence J Eckel; David A Schomas; Caterina Giannini; Fredric B Meyer Journal: J Neurosurg Date: 2012-09-07 Impact factor: 5.115
Authors: Roy W R Dudley; Michelle R Torok; Sarah Randall; Benjamin Béland; Michael H Handler; Jean M Mulcahy-Levy; Arthur K Liu; Todd C Hankinson Journal: J Neurooncol Date: 2018-03-09 Impact factor: 4.130
Authors: J H Harreld; S N Hwang; I Qaddoumi; R G Tatevossian; X Li; J Dalton; K Haupfear; Y Li; D W Ellison Journal: AJNR Am J Neuroradiol Date: 2016-07-28 Impact factor: 3.825
Authors: Alvaro Lassaletta; Michal Zapotocky; Eric Bouffet; Cynthia Hawkins; Uri Tabori Journal: Childs Nerv Syst Date: 2016-09-20 Impact factor: 1.475
Authors: Ibrahim Qaddoumi; Wilda Orisme; Ji Wen; Teresa Santiago; Kirti Gupta; James D Dalton; Bo Tang; Kelly Haupfear; Chandanamali Punchihewa; John Easton; Heather Mulder; Kristy Boggs; Ying Shao; Michael Rusch; Jared Becksfort; Pankaj Gupta; Shuoguo Wang; Ryan P Lee; Daniel Brat; V Peter Collins; Sonika Dahiya; David George; William Konomos; Kathreena M Kurian; Kathryn McFadden; Luciano Neder Serafini; Hilary Nickols; Arie Perry; Sheila Shurtleff; Amar Gajjar; Fredrick A Boop; Paul D Klimo; Elaine R Mardis; Richard K Wilson; Suzanne J Baker; Jinghui Zhang; Gang Wu; James R Downing; Ruth G Tatevossian; David W Ellison Journal: Acta Neuropathol Date: 2016-01-25 Impact factor: 17.088