Alexandra Gonçalves1, Brian Claggett2, Pardeep S Jhund3, Wayne Rosamond4, Anita Deswal5, David Aguilar6, Amil M Shah2, Susan Cheng2, Scott D Solomon7. 1. Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA University of Porto Medical School, Porto, Portugal. 2. Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. 3. Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. 4. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. 5. Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX, USA. 6. Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 7. Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA ssolomon@rics.bwh.harvard.edu.
Abstract
AIM: Alcohol is a known cardiac toxin and heavy consumption can lead to heart failure (HF). However, the relationship between moderate alcohol consumption and risk for HF, in either men or women, remains unclear. METHODS AND RESULTS: We examined 14 629 participants of the Atherosclerosis Risk in Communities (ARIC) study (54 ± 6 years, 55% women) without prevalent HF at baseline (1987-89) who were followed for 24 ± 1 years. Self-reported alcohol consumption was assessed as the number of drinks/week (1 drink = 14 g of alcohol) at baseline, and updated cumulative average alcohol intake was calculated over 8.9 ± 0.3 years. Using multivariable Cox proportional hazards models, we examined the relation of alcohol intake with incident HF and assessed whether associations were modified by sex. Overall, most participants were abstainers (42%) or former drinkers (19%), with 25% reporting up to 7 drinks per week, 8% reporting ≥7 to 14 drinks per week, and 3% reporting ≥14-21 and ≥21 drinks per week, respectively. Incident HF occurred in 1271 men and 1237 women. Men consuming up to 7 drinks/week had reduced risk of HF relative to abstainers (hazard ratio, HR 0.80, 95% CI 0.68-0.94, P = 0.006); this effect was less robust in women (HR 0.84, 95% CI 0.71-1.00, P = 0.05). In the higher drinking categories, the risk of HF was not significantly different from abstainers, either in men or in women. CONCLUSION: In the community, alcohol consumption of up to 7 drinks/week at early-middle age is associated with lower risk for future HF, with a similar but less definite association in women than in men. These findings suggest that despite the dangers of heavy drinking, modest alcohol consumption in early-middle age may be associated with a lower risk for HF. Published on behalf of the European Society of Cardiology. All rights reserved.
AIM: Alcohol is a known cardiac toxin and heavy consumption can lead to heart failure (HF). However, the relationship between moderate alcohol consumption and risk for HF, in either men or women, remains unclear. METHODS AND RESULTS: We examined 14 629 participants of the Atherosclerosis Risk in Communities (ARIC) study (54 ± 6 years, 55% women) without prevalent HF at baseline (1987-89) who were followed for 24 ± 1 years. Self-reported alcohol consumption was assessed as the number of drinks/week (1 drink = 14 g of alcohol) at baseline, and updated cumulative average alcohol intake was calculated over 8.9 ± 0.3 years. Using multivariable Cox proportional hazards models, we examined the relation of alcohol intake with incident HF and assessed whether associations were modified by sex. Overall, most participants were abstainers (42%) or former drinkers (19%), with 25% reporting up to 7 drinks per week, 8% reporting ≥7 to 14 drinks per week, and 3% reporting ≥14-21 and ≥21 drinks per week, respectively. Incident HF occurred in 1271 men and 1237 women. Men consuming up to 7 drinks/week had reduced risk of HF relative to abstainers (hazard ratio, HR 0.80, 95% CI 0.68-0.94, P = 0.006); this effect was less robust in women (HR 0.84, 95% CI 0.71-1.00, P = 0.05). In the higher drinking categories, the risk of HF was not significantly different from abstainers, either in men or in women. CONCLUSION: In the community, alcohol consumption of up to 7 drinks/week at early-middle age is associated with lower risk for future HF, with a similar but less definite association in women than in men. These findings suggest that despite the dangers of heavy drinking, modest alcohol consumption in early-middle age may be associated with a lower risk for HF. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: J M Gaziano; T A Gaziano; R J Glynn; H D Sesso; U A Ajani; M J Stampfer; J E Manson; C H Hennekens; J E Buring Journal: J Am Coll Cardiol Date: 2000-01 Impact factor: 24.094
Authors: Wayne D Rosamond; Patricia P Chang; Chris Baggett; Anna Johnson; Alain G Bertoni; Eyal Shahar; Anita Deswal; Gerardo Heiss; Lloyd E Chambless Journal: Circ Heart Fail Date: 2012-01-23 Impact factor: 8.790
Authors: Craig R Walsh; Martin G Larson; Jane C Evans; Luc Djousse; R Curtis Ellison; Ramachandran S Vasan; Daniel Levy Journal: Ann Intern Med Date: 2002-02-05 Impact factor: 25.391
Authors: Flávio D Fuchs; Lloyd E Chambless; Aaron R Folsom; Marsha L Eigenbrodt; Bruce B Duncan; Adam Gilbert; Moyses Szklo Journal: Am J Epidemiol Date: 2004-09-01 Impact factor: 4.897
Authors: David Aguilar; Hicham Skali; Lemuel A Moyé; Eldrin F Lewis; J Michael Gaziano; John D Rutherford; L Howard Hartley; Otelio S Randall; Edward M Geltman; Gervasio A Lamas; Jean L Rouleau; Marc A Pfeffer; Scott D Solomon Journal: J Am Coll Cardiol Date: 2004-06-02 Impact factor: 24.094
Authors: E C Mathews; J M Gardin; W L Henry; A A Del Negro; R D Fletcher; J A Snow; S E Epstein Journal: Am J Cardiol Date: 1981-03 Impact factor: 2.778
Authors: Natalie E Chichetto; Michael W Plankey; Alison G Abraham; David S Sheps; Nicole Ennis; Xinguang Chen; Kathleen M Weber; Steven Shoptaw; Robert C Kaplan; Wendy S Post; Robert L Cook Journal: Alcohol Clin Exp Res Date: 2019-02-28 Impact factor: 3.455
Authors: Daisuke Kamimura; Takeki Suzuki; Michael E Hall; Wanmei Wang; Michael D Winniford; Amil M Shah; Carlos J Rodriguez; Kenneth R Butler; Thomas H Mosley Journal: J Cardiol Date: 2017-12-06 Impact factor: 3.159
Authors: Alexandra Gonçalves; Pardeep S Jhund; Brian Claggett; Amil M Shah; Suma Konety; Kenneth Butler; Dalane W Kitzman; Wayne Rosamond; Flavio D Fuchs; Scott D Solomon Journal: Circ Cardiovasc Imaging Date: 2015-06 Impact factor: 7.792
Authors: Hideaki Suzuki; Wenjia Bai; Evangelos Evangelou; Raha Pazoki; He Gao; Paul M Matthews; Paul Elliott Journal: Elife Date: 2021-06-01 Impact factor: 8.713
Authors: Lisa B VanWagner; Hongyan Ning; Norrina B Allen; Veeral Ajmera; Cora E Lewis; John Jeffrey Carr; Donald M Lloyd-Jones; Norah A Terrault; Juned Siddique Journal: Gastroenterology Date: 2017-08-09 Impact factor: 33.883