| Literature DB >> 2560174 |
M R Kozlowski1, M P Rosser, E Hall, A Longden.
Abstract
PC-12 cells are used as a model for neuronal differentiation because they assume a neuronal phenotype, including the extension of neurites, when exposed to nerve growth factor (NGF). The present results show that bradykinin (BK) also causes PC-12 cells to extend neurites. In addition, BK potentiates the neurite-extending effect of nerve growth factor (NGF), an action which is attenuated by a BK antagonist. The potentiation of neurite extension produced by the combination of BK and NGF may be mediated at the receptor level, as indicated by an NGF-induced alteration of BK binding.Entities:
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Year: 1989 PMID： 2560174 DOI： 10.1016/0196-9781(89)90002-8
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750