AIM: The changes in liver function tests (LFTs) after laparoscopic cholecystectomy (LC) have been described in the literature. The aims of this study are to value the increases of the LFTs and its clinical appearance after LC. Furthermore we studied the correlation of the changes of LFTs with the operative time and the role of elevated BMI. MATERIAL OF STUDY: In the period October 2012 - May 2013, 81 patients undergone to elective LC were analyzed by examining bilirubin, AST, ALT, ALP, GGT at the admission, 1 and 3 days after surgery. Correlations of the length of intervention and BMI with changes of LFTs are evaluated. During surgery, the intrabdominal pressure has been 12 mmHg in all patients. The Student t test, PCC (Pearson's correlation coefficient) OR (odds ratio) were performed to determine statistical significance. RESULTS: The level of (serum) AST, ALT increased significantly during 24-48 hours after LC (p < 0,0001). The increase of (total and direct) bilirubin has not the statistical significance. On the contrary ALP, GGT was significantly decreased (p < 0,001). Three days after surgery LFTs returned to normal level in the patients with previous normal level of tests. The length of intervention doesn't show correlations with changes of LFTs (PCC 0.2). the BMI >28 led increased risk of changes of LFTs (OR 2.44). CONCLUSIONS: The changes of LFTs are transient and clinically silent in patients with a normal liver function. Nevertheless must be evaluated preoperative BMI and liver dysfunction.
AIM: The changes in liver function tests (LFTs) after laparoscopic cholecystectomy (LC) have been described in the literature. The aims of this study are to value the increases of the LFTs and its clinical appearance after LC. Furthermore we studied the correlation of the changes of LFTs with the operative time and the role of elevated BMI. MATERIAL OF STUDY: In the period October 2012 - May 2013, 81 patients undergone to elective LC were analyzed by examining bilirubin, AST, ALT, ALP, GGT at the admission, 1 and 3 days after surgery. Correlations of the length of intervention and BMI with changes of LFTs are evaluated. During surgery, the intrabdominal pressure has been 12 mmHg in all patients. The Student t test, PCC (Pearson's correlation coefficient) OR (odds ratio) were performed to determine statistical significance. RESULTS: The level of (serum) AST, ALT increased significantly during 24-48 hours after LC (p < 0,0001). The increase of (total and direct) bilirubin has not the statistical significance. On the contrary ALP, GGT was significantly decreased (p < 0,001). Three days after surgery LFTs returned to normal level in the patients with previous normal level of tests. The length of intervention doesn't show correlations with changes of LFTs (PCC 0.2). the BMI >28 led increased risk of changes of LFTs (OR 2.44). CONCLUSIONS: The changes of LFTs are transient and clinically silent in patients with a normal liver function. Nevertheless must be evaluated preoperative BMI and liver dysfunction.
Authors: Nicola Tartaglia; Giovanna Pavone; Alessandra Di Lascia; Fernanda Vovola; Francesca Maddalena; Alberto Fersini; Mario Pacilli; Antonio Ambrosi Journal: J Med Case Rep Date: 2020-02-04
Authors: Nicola Tartaglia; Alessandra Di Lascia; Pasquale Cianci; Alberto Fersini; Mario Pacilli; Giovanna Pavone; Antonio Ambrosi Journal: Open Med (Wars) Date: 2020-08-03