| Literature DB >> 25600653 |
Tom A Targel1, Jayprakash N Kumar, O Svetlana Shneider, Sukanta Bar, Natalia Fridman, Shimon Maximenko, Alex M Szpilman.
Abstract
Umpolung alkylation of Evans' auxiliary substituted β-ketoimides affords the diastereomerically pure products in yields ranging from 40 to 80%. The reaction itself proceeds with diastereoselectivities between 3 : 1 and 18 : 1. Dialkylzinc serves as the nucleophile and umpolung of the β-keto-imide enolate is achieved by the action of Koser's reagent.Entities:
Year: 2015 PMID： 25600653 DOI： 10.1039/c4ob02601b
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876