Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation.

Literature DB >> 25600489

Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation.

Genovefa A Papanicolaou¹, Yeon Joo Lee², James W Young³, Surya V Seshan⁴, Adam M Boruchov⁵, Gregory Chittick⁶, Herve Momméja-Marin⁶, Ilya G Glezerman⁷.

Abstract

Polyomavirus-associated nephropathy (PVAN) is common in patients who have undergone kidney transplantation and has been reported in hematopoietic stem cell (HSC) transplant recipients. Aside from reduction of immunosuppression, few therapeutic options exist for treatment of PVAN. We report a case of PVAN in a severely immunocompromised allogeneic HSC transplant recipient that was treated with brincidofovir without reduction of immunosuppression. We review our institutional experience of PVAN in HSC transplantation and discuss the potential use of brincidofovir for treatment.

Entities: CellLine Chemical Disease Gene Species

Keywords: BK viremia; BK virus; Polyomavirus-associated nephropathy (PVAN); brincidofovir; hematopoietic stem cell (HSC) transplantation; kidney failure

Mesh：

Substances：

Year: 2015 PMID： 25600489 PMCID： PMC5916792 DOI： 10.1053/j.ajkd.2014.11.020

Source DB: PubMed Journal: Am J Kidney Dis ISSN： 0272-6386 Impact factor: 8.860

19 in total

1. BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants.

Authors: Peter H O'Donnell; Kate Swanson; Michelle A Josephson; Andrew S Artz; Sandeep D Parsad; Charulata Ramaprasad; Kenneth Pursell; Elizabeth Rich; Wendy Stock; Koen van Besien
Journal: Biol Blood Marrow Transplant Date: 2009-07-09 Impact factor: 5.742

2. Treatment of BK viremia after renal transplantation: are fluoroquinolones a false dawn?

Authors: Siddiq Anwar; Daniel C Brennan
Journal: Clin J Am Soc Nephrol Date: 2014-01-30 Impact factor: 8.237

Review 3. Management of polyomavirus-associated nephropathy in renal transplant recipients.

Authors: Dirk R J Kuypers
Journal: Nat Rev Nephrol Date: 2012-04-17 Impact factor: 28.314

4. BK virus nephropathy in a pediatric autologous stem-cell transplant recipient.

Authors: L Nelson Sanchez-Pinto; Benjamin L Laskin; Sonata Jodele; Trent R Hummel; Hong J Yin; Jens Goebel
Journal: Pediatr Blood Cancer Date: 2010-11-11 Impact factor: 3.167

5. Polyomavirus nephropathy in native kidneys of non-renal transplant recipients.

Authors: Ajit P Limaye; Kelly D Smith; Linda Cook; Debra A Groom; Nicholas C Hunt; Keith R Jerome; Michael Boeckh
Journal: Am J Transplant Date: 2005-03 Impact factor: 8.086

6. 1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells.

Authors: Christine Hanssen Rinaldo; Rainer Gosert; Eva Bernhoff; Solrun Finstad; Hans H Hirsch
Journal: Antimicrob Agents Chemother Date: 2010-08-16 Impact factor: 5.191

Review 7. BK virus nephropathy after allogeneic stem cell transplantation: a case report and literature review.

Authors: Lazaros J Lekakis; Valentina Macrinici; Ioannis G Baraboutis; Bonnie Mitchell; Dianna S Howard
Journal: Am J Hematol Date: 2009-04 Impact factor: 10.047

8. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation.

Authors: Francisco M Marty; Drew J Winston; Scott D Rowley; Estil Vance; Genovefa A Papanicolaou; Kathleen M Mullane; Thomas M Brundage; Alice T Robertson; Susan Godkin; Hervé Momméja-Marin; Michael Boeckh
Journal: N Engl J Med Date: 2013-09-26 Impact factor: 91.245

9. Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

Authors: Stephanie L Ciesla; Julissa Trahan; W Brad Wan; James R Beadle; Kathy A Aldern; George R Painter; Karl Y Hostetler
Journal: Antiviral Res Date: 2003-08 Impact factor: 5.970

10. BK nephropathy in pediatric hematopoietic stem cell transplant recipients.

Authors: Priya S Verghese; Laura S Finn; Janet A Englund; Jean E Sanders; Sangeeta R Hingorani
Journal: Pediatr Transplant Date: 2008-11-01

7 in total

1. Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis.

Authors: Melissa Krystel-Whittemore; Ellen T McCarthy; Ivan Damjanov; Timothy A Fields
Journal: BMJ Case Rep Date: 2015-08-28

2. Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD.

Authors: Claire J Detweiler; Sarah B Mueller; Anthony D Sung; Jennifer L Saullo; Vinod K Prasad; Diana M Cardona
Journal: J Pediatr Hematol Oncol Date: 2018-08 Impact factor: 1.289

Review 3. BK Polyomavirus: Clinical Aspects, Immune Regulation, and Emerging Therapies.

Authors: George R Ambalathingal; Ross S Francis; Mark J Smyth; Corey Smith; Rajiv Khanna
Journal: Clin Microbiol Rev Date: 2017-04 Impact factor: 26.132

4. Symptomatic BK Virus Infection Is Associated With Kidney Function Decline and Poor Overall Survival in Allogeneic Hematopoietic Stem Cell Recipients.

Authors: A Abudayyeh; A Hamdi; H Lin; M Abdelrahim; G Rondon; B S Andersson; A Afrough; C S Martinez; J J Tarrand; D P Kontoyiannis; D Marin; A O Gaber; A Salahudeen; B Oran; R F Chemaly; A Olson; R Jones; U Popat; R E Champlin; E J Shpall; W C Winkelmayer; K Rezvani
Journal: Am J Transplant Date: 2016-03-02 Impact factor: 8.086