Wenjie Sun1, Chi-Pang Wen2, Jie Lin3, Christopher Wen4, Xia Pu3, Maosheng Huang3, Min Kuang Tsai5, Chwen Keng Tsao6, Xifeng Wu7, Wong-Ho Chow3. 1. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. 2. Institute of Population Health Science, National Health Research Institutes, Zhunan, Taiwan; China Medical University Hospital, Taichung, Taiwan. 3. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 4. Department of Radiological Sciences, University of California at Irvine, Irvine, CA, USA. 5. Institute of Population Health Science, National Health Research Institutes, Zhunan, Taiwan. 6. MJ Health Management Institution, Taipei, Taiwan. 7. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xwu@mdanderson.org.
Abstract
BACKGROUND: The associations of laboratory-based ABO phenotypes with cancer risks and mortality have not been systematically determined. METHODS: The study subjects were 339,432 healthy individuals with laboratory-based blood types from a Taiwan cohort. RESULTS: Compared to blood type O, blood type A was significantly associated with an elevated risk of stomach cancer incidence (Hazard Ratio [HR], 1.38 [95% CI, 1.11-1.72]) and mortality (HR, 1.38 [95% CI, 1.02-1.86]) compared with blood type O, after adjusting for age, sex, education, smoking, alcohol drinking, physical activity, and body mass index. Non-O blood types were associated with an elevated risk of pancreatic cancer, with blood type B reaching statistical significance for incidence (HR, 1.59 [95% CI, 1.02-2.48]) and mortality (HR, 1.63 [95% CI, 1.02-2.60]). In contrast, kidney cancer risk was inversely associated with blood type AB (HR, 0.41 [95% CI, 0.18-0.93]) compared to type O. CONCLUSION: Cancer risks vary in people with different ABO blood types, with elevated risks of stomach cancer associated with blood type A and pancreatic cancer associated with non-O blood types (A, B, and AB).
BACKGROUND: The associations of laboratory-based ABO phenotypes with cancer risks and mortality have not been systematically determined. METHODS: The study subjects were 339,432 healthy individuals with laboratory-based blood types from a Taiwan cohort. RESULTS: Compared to blood type O, blood type A was significantly associated with an elevated risk of stomach cancer incidence (Hazard Ratio [HR], 1.38 [95% CI, 1.11-1.72]) and mortality (HR, 1.38 [95% CI, 1.02-1.86]) compared with blood type O, after adjusting for age, sex, education, smoking, alcohol drinking, physical activity, and body mass index. Non-O blood types were associated with an elevated risk of pancreatic cancer, with blood type B reaching statistical significance for incidence (HR, 1.59 [95% CI, 1.02-2.48]) and mortality (HR, 1.63 [95% CI, 1.02-2.60]). In contrast, kidney cancer risk was inversely associated with blood type AB (HR, 0.41 [95% CI, 0.18-0.93]) compared to type O. CONCLUSION:Cancer risks vary in people with different ABO blood types, with elevated risks of stomach cancer associated with blood type A and pancreatic cancer associated with non-O blood types (A, B, and AB).
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