BACKGROUND: Reliable prognostic tools to estimate the case fatality rate (CFR) and the development of chronic hydrocephalus (CHC) in aneurysmal subarachnoid hemorrhage (SAH) are not well defined. This study aims to investigate the practicability and reliability of Fisher, Graeb, and LeRoux scores for SAH patient prognosis. METHODS: A total of 206 patients with aneurysmal SAH were retrospectively analyzed in prediction of CFR and CHC. Clinical data was evaluated and grading was performed using Fisher, Graeb, and LeRoux scores. Univariate and multivariate analyses were performed to identify relevant predictive parameters. RESULTS: CFR was 17.0 % and was associated with higher age, higher Hunt & Hess (H&H) grade, lower Glasgow Coma Scale (GCS) at admission, as well as a higher Fisher, Graeb, and LeRoux score (p < 0.001). There were 19.9 % that developed CHC requiring permanent cerebrospinal fluid diversion. Low initial GCS (p = 0.003), high H&H (p < 0.001), intracerebral hematoma (p = 0.003), high Fisher (p = 0.047), Graeb and LeRoux scores (p < 0.001) were associated with a higher rate of ventricular-peritoneal shunting (VPS) in surviving patients. In multivariate analyses, Graeb score (odds ratio (OR) 1.183 [1.027, 1.363], p = 0.020), LeRoux score (OR 1.120 [1.013-1.239, p = 0.027), and H&H (OR 2.715 [1.496, 4.927], p = 0.001) remained independent prognostic factors for VPS. CONCLUSIONS: Graeb or LeRoux scores improve the prediction of shunt dependency and in parts of CFR in aneurysmal SAH patients therefore confirming the relevance of the extent and distribution of intraventricular blood for the clinical course in SAH.
BACKGROUND: Reliable prognostic tools to estimate the case fatality rate (CFR) and the development of chronic hydrocephalus (CHC) in aneurysmal subarachnoid hemorrhage (SAH) are not well defined. This study aims to investigate the practicability and reliability of Fisher, Graeb, and LeRoux scores for SAHpatient prognosis. METHODS: A total of 206 patients with aneurysmalSAH were retrospectively analyzed in prediction of CFR and CHC. Clinical data was evaluated and grading was performed using Fisher, Graeb, and LeRoux scores. Univariate and multivariate analyses were performed to identify relevant predictive parameters. RESULTS: CFR was 17.0 % and was associated with higher age, higher Hunt & Hess (H&H) grade, lower Glasgow Coma Scale (GCS) at admission, as well as a higher Fisher, Graeb, and LeRoux score (p < 0.001). There were 19.9 % that developed CHC requiring permanent cerebrospinal fluid diversion. Low initial GCS (p = 0.003), high H&H (p < 0.001), intracerebral hematoma (p = 0.003), high Fisher (p = 0.047), Graeb and LeRoux scores (p < 0.001) were associated with a higher rate of ventricular-peritoneal shunting (VPS) in surviving patients. In multivariate analyses, Graeb score (odds ratio (OR) 1.183 [1.027, 1.363], p = 0.020), LeRoux score (OR 1.120 [1.013-1.239, p = 0.027), and H&H (OR 2.715 [1.496, 4.927], p = 0.001) remained independent prognostic factors for VPS. CONCLUSIONS: Graeb or LeRoux scores improve the prediction of shunt dependency and in parts of CFR in aneurysmalSAHpatients therefore confirming the relevance of the extent and distribution of intraventricular blood for the clinical course in SAH.
Authors: David Y Chung; Bradford B Thompson; Monisha A Kumar; Ali Mahta; Shyam S Rao; James H Lai; Aleksey Tadevosyan; Kathryn Kessler; Joseph J Locascio; Aman B Patel; Wazim Mohamed; DaiWai M Olson; Sayona John; Guy A Rordorf Journal: Neurocrit Care Date: 2021-09-08 Impact factor: 3.532
Authors: Julia S Bretz; Falk Von Dincklage; Johannes Woitzik; Maren K L Winkler; Sebastian Major; Jens P Dreier; Georg Bohner; Michael Scheel Journal: Clin Neuroradiol Date: 2016-04-25 Impact factor: 3.649
Authors: Hae Gi Park; Sunghan Kim; Joonho Chung; Chang Ki Jang; Keun Young Park; Jae Whan Lee Journal: BMC Neurol Date: 2021-12-11 Impact factor: 2.474