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Literature DB >> 25599885

The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice.

Yanqing Zang¹, Liping Zhang, Kiharu Igarashi, Changqing Yu.

Abstract

The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed of four kaempferol glycosides and purified from unripe Jindai-soybean (Edamame) leaves in C57BL/6J mice. High fat-fed mice treated with 0.15% dietary KG for 92 days had reduced body weight, adipose tissue and TG levels compared to the high fat-fed control group. KG-treatment also decreased fasting blood glucose, serum HbA1c (hemoglobin A(1c)) levels and improved insulin resistance. Gene expression analysis of the liver showed that KG decreased peroxisome proliferator-activated receptor (PPAR-γ) and sterol regulatory element-binding protein (SREBP-1c) expression. These results suggest that KG reduced the accumulation of adipose tissue, improving hyperlipidemia as well as diabetes in obese mice by increasing lipid metabolism through the downregulation of PPAR-γ and SREBP-1c. Thus, KG may have an anti-obesity and anti-diabetic potential.

Entities: Chemical Disease Gene Species

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Year: 2015 PMID： 25599885 DOI： 10.1039/c4fo00844h

Source DB: PubMed Journal: Food Funct ISSN： 2042-6496 Impact factor: 5.396

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Cited

27 in total

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The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice.

1. Glycine max Merr. leaf extract possesses anti-oxidant properties, decreases inflammatory mediator production in murine macrophages, and inhibits growth, migration, and adhesion in human cancer cells.

2. Antioxidant and hepatoprotective activity of kaempferol 3-O-β-d- (2,6-di-O-α-l-rhamnopyranosyl)galactopyronoside against carbon tetrachloride-induced liver injury in mice.

3. Antileishmanial Activity of Lignans, Neolignans, and Other Plant Phenols.

Review 4. The potential role of phenolic compounds on modulating gut microbiota in obesity.

Review 5. Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease.

Review 6. Antidiabetic properties of dietary flavonoids: a cellular mechanism review.

Review 7. Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids.

Review 8. Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target.

9. Influence of Flavonoids on Mechanism of Modulation of Insulin Secretion.

10. Lemon Extract Reduces Angiotensin Converting Enzyme (ACE) Expression and Activity and Increases Insulin Sensitivity and Lipolysis in Mouse Adipocytes.