Literature DB >> 25599532

The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine.

Stéphane Cociancich1, Alexander Pesic2, Daniel Petras2, Stefanie Uhlmann2, Julian Kretz2, Vivien Schubert2, Laura Vieweg2, Sandrine Duplan1, Mélanie Marguerettaz1, Julie Noëll1, Isabelle Pieretti1, Manuela Hügelland2, Sebastian Kemper2, Andi Mainz2, Philippe Rott1, Monique Royer1, Roderich D Süssmuth2.   

Abstract

Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.

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Year:  2015        PMID： 25599532     DOI： 10.1038/nchembio.1734

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  22 in total

1.  Analysis of the genes flanking xabB: a methyltransferase gene is involved in albicidin biosynthesis in Xanthomonas albilineans.

Authors:  G Huang; L Zhang; R G Birch
Journal:  Gene       Date:  2000-09-19       Impact factor: 3.688

Review 2.  A metabolic node in action: chorismate-utilizing enzymes in microorganisms.

Authors:  F Dosselaere; J Vanderleyden
Journal:  Crit Rev Microbiol       Date:  2001       Impact factor: 7.624

3.  Conformational switches modulate protein interactions in peptide antibiotic synthetases.

Authors:  Alexander Koglin; Mohammad R Mofid; Frank Löhr; Birgit Schäfer; Vladimir V Rogov; Marc-Michael Blum; Tanja Mittag; Mohamed A Marahiel; Frank Bernhard; Volker Dötsch
Journal:  Science       Date:  2006-04-14       Impact factor: 47.728

4.  Screening of fusion partners for high yield expression and purification of bioactive viscotoxins.

Authors:  Julius Bogomolovas; Bernd Simon; Michael Sattler; Gunter Stier
Journal:  Protein Expr Purif       Date:  2008-10-17       Impact factor: 1.650

5.  A multilocus sequence analysis of the genus Xanthomonas.

Authors:  J M Young; D-C Park; H M Shearman; E Fargier
Journal:  Syst Appl Microbiol       Date:  2008-09-10       Impact factor: 4.022

6.  Factors affecting biosynthesis by Xanthomonas albilineans of albicidin antibiotics and phytotoxins.

Authors:  L Zhang; J Xu; R G Birch
Journal:  J Appl Microbiol       Date:  1998-12       Impact factor: 3.772

Review 7.  The ATP-binding site of type II topoisomerases as a target for antibacterial drugs.

Authors:  Anthony Maxwell; David M Lawson
Journal:  Curr Top Med Chem       Date:  2003       Impact factor: 3.295

8.  I-TASSER server for protein 3D structure prediction.

Authors:  Yang Zhang
Journal:  BMC Bioinformatics       Date:  2008-01-23       Impact factor: 3.169

9.  The phytotoxin albicidin is a novel inhibitor of DNA gyrase.

Authors:  Saeed M Hashimi; Melisa K Wall; Andrew B Smith; Anthony Maxwell; Robert G Birch
Journal:  Antimicrob Agents Chemother       Date:  2006-10-30       Impact factor: 5.191

10.  Analysis Tool Web Services from the EMBL-EBI.

Authors:  Hamish McWilliam; Weizhong Li; Mahmut Uludag; Silvano Squizzato; Young Mi Park; Nicola Buso; Andrew Peter Cowley; Rodrigo Lopez
Journal:  Nucleic Acids Res       Date:  2013-05-13       Impact factor: 16.971
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  27 in total

1.  A chemocentric view of the natural product inventory.

Authors:  Christopher T Walsh
Journal:  Nat Chem Biol       Date:  2015-09       Impact factor: 15.040

2.  Assembly and clustering of natural antibiotics guides target identification.

Authors:  Chad W Johnston; Michael A Skinnider; Chris A Dejong; Philip N Rees; Gregory M Chen; Chelsea G Walker; Shawn French; Eric D Brown; János Bérdy; Dennis Y Liu; Nathan A Magarvey
Journal:  Nat Chem Biol       Date:  2016-02-01       Impact factor: 15.040

3.  Natural products: untwisting the antibiotic'ome.

Authors:  Chad W Johnston; Nathan A Magarvey
Journal:  Nat Chem Biol       Date:  2015-03       Impact factor: 15.040

4.  Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria.

Authors:  Joachim J Hug; Fabian Panter; Daniel Krug; Rolf Müller
Journal:  J Ind Microbiol Biotechnol       Date:  2018-12-01       Impact factor: 3.346

5.  Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II.

Authors:  Stephen A Cochrane; Brandon Findlay; Alireza Bakhtiary; Jeella Z Acedo; Eva M Rodriguez-Lopez; Pascal Mercier; John C Vederas
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-29       Impact factor: 11.205

6.  The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.

Authors:  Wenlong Cai; Anwesha Goswami; Zhaoyong Yang; Xiaodong Liu; Keith D Green; Sandra Barnard-Britson; Satoshi Baba; Masanori Funabashi; Koichi Nonaka; Manjula Sunkara; Andrew J Morris; Anatol P Spork; Christian Ducho; Sylvie Garneau-Tsodikova; Jon S Thorson; Steven G Van Lanen
Journal:  J Biol Chem       Date:  2015-04-08       Impact factor: 5.157

7.  Mechanisms of Resistance to the Contact-Dependent Bacteriocin CdzC/D in Caulobacter crescentus.

Authors:  Leonor García-Bayona; Kevin Gozzi; Michael T Laub
Journal:  J Bacteriol       Date:  2019-03-26       Impact factor: 3.490

8.  Protective effect of Qnr on agents other than quinolones that target DNA gyrase.

Authors:  George A Jacoby; Marian A Corcoran; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191

9.  The hidden enzymology of bacterial natural product biosynthesis.

Authors:  Thomas A Scott; Jörn Piel
Journal:  Nat Rev Chem       Date:  2019-06-12       Impact factor: 34.035

10.  Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy.

Authors:  Giambattista Testolin; Katarina Cirnski; Katharina Rox; Hans Prochnow; Verena Fetz; Charlotte Grandclaudon; Tim Mollner; Alain Baiyoumy; Antje Ritter; Christian Leitner; Jana Krull; Joop van den Heuvel; Aurelie Vassort; Sylvie Sordello; Mostafa M Hamed; Walid A M Elgaher; Jennifer Herrmann; Rolf W Hartmann; Rolf Müller; Mark Brönstrup
Journal:  Chem Sci       Date:  2019-12-10       Impact factor: 9.825
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