| Literature DB >> 25599400 |
Matthias Merker1, Camille Blin2, Stefano Mona2, Nicolas Duforet-Frebourg3, Sophie Lecher4, Eve Willery4, Michael G B Blum3, Sabine Rüsch-Gerdes5, Igor Mokrousov6, Eman Aleksic7, Caroline Allix-Béguec8, Annick Antierens9, Ewa Augustynowicz-Kopeć10, Marie Ballif11, Francesca Barletta12, Hans Peter Beck13, Clifton E Barry14, Maryline Bonnet15, Emanuele Borroni16, Isolina Campos-Herrero17, Daniela Cirillo16, Helen Cox18, Suzanne Crowe19, Valeriu Crudu20, Roland Diel21, Francis Drobniewski22, Maryse Fauville-Dufaux23, Sébastien Gagneux13, Solomon Ghebremichael24, Madeleine Hanekom25, Sven Hoffner26, Wei-wei Jiao27, Stobdan Kalon28, Thomas A Kohl1, Irina Kontsevaya29, Troels Lillebæk30, Shinji Maeda31, Vladyslav Nikolayevskyy22, Michael Rasmussen30, Nalin Rastogi32, Sofia Samper33, Elisabeth Sanchez-Padilla15, Branislava Savic34, Isdore Chola Shamputa14, Adong Shen27, Li-Hwei Sng35, Petras Stakenas36, Kadri Toit37, Francis Varaine38, Dragana Vukovic34, Céline Wahl8, Robin Warren25, Philip Supply39, Stefan Niemann40, Thierry Wirth2.
Abstract
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.Entities:
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Year: 2015 PMID： 25599400 DOI： 10.1038/ng.3195
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330