Richard N Re1. 1. Research Division, Ochsner Health System, New Orleans, LA.
Abstract
BACKGROUND: Intracrinology is the study of the intracellular actions, regulation, trafficking, and interactions of extracellular signaling peptides/proteins. METHODS: We describe the development of intracrine biology since the term was defined in 1984. RESULTS: Intracrine biology plays a role in many normal and pathological processes and represents a fertile field for the development of novel therapeutics. CONCLUSION: Although 30 years old, the field of intracrinology is only now becoming widely accepted. Intracrine principles can be applied to the investigation of physiological processes and to the development of new therapies.
BACKGROUND: Intracrinology is the study of the intracellular actions, regulation, trafficking, and interactions of extracellular signaling peptides/proteins. METHODS: We describe the development of intracrine biology since the term was defined in 1984. RESULTS: Intracrine biology plays a role in many normal and pathological processes and represents a fertile field for the development of novel therapeutics. CONCLUSION: Although 30 years old, the field of intracrinology is only now becoming widely accepted. Intracrine principles can be applied to the investigation of physiological processes and to the development of new therapies.
Keywords:
Angiotensin II; cytoplasmic and nuclear receptors; intracellular signaling peptides and proteins; intracrine; intracrinology; renin-angiotensin systems
Authors: Jenny E Felin; Jaime L Mayo; Trina J Loos; J Daniel Jensen; Daniel K Sperry; Stephanie L Gaufin; Christopher A Meinhart; Jennie B Moss; Laura C Bridgewater Journal: BMC Cell Biol Date: 2010-03-15 Impact factor: 4.241
Authors: Laura Ferrer-Soler; Alejandro Vazquez-Martin; Joan Brunet; Javier A Menendez; Rafael De Llorens; Ramon Colomer Journal: Int J Mol Med Date: 2007-07 Impact factor: 4.101
Authors: Tim N Beck; Vladislav A Korobeynikov; Alexander E Kudinov; Rachel Georgopoulos; Nehal R Solanki; Magda Andrews-Hoke; Timothy M Kistner; David Pépin; Patricia K Donahoe; Emmanuelle Nicolas; Margret B Einarson; Yan Zhou; Yanis Boumber; David A Proia; Ilya G Serebriiskii; Erica A Golemis Journal: Cell Rep Date: 2016-07-07 Impact factor: 9.423