Literature DB >> 2559794

Hepatitis B virus and hepatocellular carcinoma--treatment of HBV carriers with Phyllanthus amarus.

B S Blumberg1, I Millman, P S Venkateswaran, S P Thyagarajan.   

Abstract

Extracts of Phyllanthus amarus inhibit the DNA polymerase of HBV and related viruses. Woodchuck carriers of woodchuck hepatitis virus (WHV) were treated intraperitoneally with P. amarus extract. Three of four animals which had been recently infected lost the virus. Animals infected for about 3 months or more had a decrease in virus levels. Human carriers of HBV were treated orally for 1 month. About 60% of the carriers lost HBV, which did not return during the observation period. Fractions containing active principles are now being isolated and characterized.

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Year:  1989        PMID: 2559794

Source DB:  PubMed          Journal:  Cancer Detect Prev        ISSN: 0361-090X


  9 in total

Review 1.  Chinese medicinal herbs for chronic hepatitis B.

Authors:  J P Liu; H McIntosh; H Lin
Journal:  Cochrane Database Syst Rev       Date:  2001

2.  Pre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus.

Authors:  Seung-Wook Chi; Do-Hyoung Kim; Si-Hyung Lee; Iksoo Chang; Kyou-Hoon Han
Journal:  Protein Sci       Date:  2007-08-31       Impact factor: 6.725

3.  Organic nitrogen stimulates caulogenesis from hypocotyl callus of Phyllanthus fraternus.

Authors:  S Rajasubramaniam; P Pardha Saradhi
Journal:  Plant Cell Rep       Date:  1994-08       Impact factor: 4.570

Review 4.  Hepatitis B virus infection and primary hepatocellular carcinoma.

Authors:  M Feitelson
Journal:  Clin Microbiol Rev       Date:  1992-07       Impact factor: 26.132

Review 5.  Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer.

Authors:  Lorne J Hofseth
Journal:  Cancer Lett       Date:  2008-04-25       Impact factor: 8.679

6.  Callus induction in Phyllanthus species and inhibition of viral DNA polymerase and reverse transcriptase by callus extracts.

Authors:  D W Unander
Journal:  Plant Cell Rep       Date:  1991-11       Impact factor: 4.570

7.  Clonal propagation of Phyllanthus amarus: A hepatoprotector.

Authors:  Janifer R Xavier; Ramaswamy Gnanam; Muthiah P Murugan; Anju Pappachan
Journal:  Pharmacogn Mag       Date:  2012-01       Impact factor: 1.085

8.  Inhibition studies of HBV DNA polymerase using seed extracts of Pongamia pinnata.

Authors:  Manikannan Mathayan; Selvaraj Jayaraman; Langeswaran Kulanthaivel; Arumugam Suresh
Journal:  Bioinformation       Date:  2019-07-31

Review 9.  Primary and secondary prevention of liver cancer caused by HBV.

Authors:  Baruch S Blumberg
Journal:  Front Biosci (Schol Ed)       Date:  2010-01-01
  9 in total

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