PURPOSE: We performed a review with the purpose to summarise, analyse and discuss the evidence provided by clinical studies evaluating effectiveness of melatonin in the cure of tinnitus. Due to the fact that there is no satisfactory treatment for tinnitus, clinical research has explored new therapeutic approaches. METHODS: A search of Pubmed, Medline, Embase, Central and Google Scholar was conducted to find trials published prior March 2014 on melatonin in the treatment of tinnitus. Design of the studies, randomization, allocation concealment procedures and diagnostic instruments (scales for tinnitus evaluation) were critical evaluated. RESULTS: Five clinical studies have been included. Three of them tested effectiveness of melatonin alone, the remaining two along with sulpiride and sulodexide respectively. Considered clinical trials adopted various experimental designs: single arm, randomised placebo-controlled and randomised placebo-controlled followed by crossover. These studies were characterised by several methodological weaknesses. CONCLUSION: Confirmation of melatonin clinical effectiveness in the treatment of tinnitus cannot be given in the light of the biases observed in the considered evidence. Melatonin seems to improve sleep disturbance linked to tinnitus.
PURPOSE: We performed a review with the purpose to summarise, analyse and discuss the evidence provided by clinical studies evaluating effectiveness of melatonin in the cure of tinnitus. Due to the fact that there is no satisfactory treatment for tinnitus, clinical research has explored new therapeutic approaches. METHODS: A search of Pubmed, Medline, Embase, Central and Google Scholar was conducted to find trials published prior March 2014 on melatonin in the treatment of tinnitus. Design of the studies, randomization, allocation concealment procedures and diagnostic instruments (scales for tinnitus evaluation) were critical evaluated. RESULTS: Five clinical studies have been included. Three of them tested effectiveness of melatonin alone, the remaining two along with sulpiride and sulodexide respectively. Considered clinical trials adopted various experimental designs: single arm, randomised placebo-controlled and randomised placebo-controlled followed by crossover. These studies were characterised by several methodological weaknesses. CONCLUSION: Confirmation of melatonin clinical effectiveness in the treatment of tinnitus cannot be given in the light of the biases observed in the considered evidence. Melatonin seems to improve sleep disturbance linked to tinnitus.
Authors: Thomas Probst; Rüdiger C Pryss; Berthold Langguth; Josef P Rauschecker; Johannes Schobel; Manfred Reichert; Myra Spiliopoulou; Winfried Schlee; Johannes Zimmermann Journal: Front Aging Neurosci Date: 2017-08-02 Impact factor: 5.750
Authors: Hadaya Mosaad Eladl; Safaa M Elkholi; Marwa M Eid; Walid Kamal Abdelbasset; Zeinab A Ali; Heba A Bahey El-Deen Journal: Medicine (Baltimore) Date: 2022-08-05 Impact factor: 1.817
Authors: Martin Schecklmann; Maximilian Pregler; Peter M Kreuzer; Timm B Poeppl; Astrid Lehner; Tatjana Crönlein; Thomas C Wetter; Elmar Frank; Michael Landgrebe; Berthold Langguth Journal: Biomed Res Int Date: 2015-10-25 Impact factor: 3.411
Authors: Ektor Tsuneo Onishi; Cláudia Couto de Barros Coelho; Jeanne Oiticica; Ricardo Rodrigues Figueiredo; Rita de Cassia Cassou Guimarães; Tanit Ganz Sanchez; Adriana Lima Gürtler; Alessandra Ramos Venosa; André Luiz Lopes Sampaio; Andreia Aparecida Azevedo; Anna Paula Batista de Ávila Pires; Bruno Borges de Carvalho Barros; Carlos Augusto Costa Pires de Oliveira; Clarice Saba; Fernando Kaoru Yonamine; Ítalo Roberto Torres de Medeiros; Letícia Petersen Schmidt Rosito; Marcelo José Abras Rates; Márcia Akemi Kii; Mariana Lopes Fávero; Mônica Alcantara de Oliveira Santos; Osmar Clayton Person; Patrícia Ciminelli; Renata de Almeida Marcondes; Ronaldo Kennedy de Paula Moreira; Sandro de Menezes Santos Torres Journal: Braz J Otorhinolaryngol Date: 2017-12-24