Literature DB >> 25597721

[Identification of proliferating cells in Taenia solium cysts].

Miguel Ángel Orrego-Solano1, Carla Cangalaya1, Theodore E Nash1, Cristina Guerra-Giraldez1.   

Abstract

Neoblasts are totipotent cells, solely responsible for the proliferation and maturation of tissues in free-living flatworms. Similar cells have been isolated from parasitic flatworms such as Echinococcus. Taenia solium causes human taeniasis (intestinal) and cysticercosis in humans and pigs. Brain infection with larvae (cysts) of T. solium results in neurocysticercosis which is hyperendemic in Peru, and its treatment is associated with serious neurological symptoms. The proliferative capacity and development stages of T. solium have not been described and the neoblasts of this parasite have not been characterized We looked for cell proliferation in T. solium cysts collected from an infected pig, which were identified when replicating and incorporating bromodeoxyuridine nucleotide detected with a monoclonal antibody. A stable cell line of neoblasts would be useful for systematic in vitro studies on drug efficacy and the biology of T. solium.

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Year:  2014        PMID: 25597721      PMCID: PMC6108088     

Source DB:  PubMed          Journal:  Rev Peru Med Exp Salud Publica        ISSN: 1726-4634


  19 in total

1.  Axenic in vitro cultivation of Echinococcus multilocularis metacestode vesicles and the generation of primary cell cultures.

Authors:  Markus Spiliotis; Klaus Brehm
Journal:  Methods Mol Biol       Date:  2009

Review 2.  Cellular and molecular dissection of pluripotent adult somatic stem cells in planarians.

Authors:  Norito Shibata; Labib Rouhana; Kiyokazu Agata
Journal:  Dev Growth Differ       Date:  2010-01       Impact factor: 2.053

3.  Autoradiographic analysis of the germinative tissue in evaginated Taenia solium metacestodes.

Authors:  M T Merchant; C Corella; K Willms
Journal:  J Parasitol       Date:  1997-06       Impact factor: 1.276

4.  On the role of germ cells in planarian regeneration. I. A karyological investigation.

Authors:  V Gremigni; C Miceli; I Puccinelli
Journal:  J Embryol Exp Morphol       Date:  1980-02

Review 5.  Clinical aspects of neurocysticercosis.

Authors:  Osvaldo M Takayanagui; Newton Satoru Odashima
Journal:  Parasitol Int       Date:  2005-12-05       Impact factor: 2.230

6.  The human nervous tissue in proximity to granulomatous lesions induced by Taenia solium metacestodes displays an active response.

Authors:  J I Alvarez; C H Colegial; C A Castaño; J Trujillo; J M Teale; B I Restrepo
Journal:  J Neuroimmunol       Date:  2002-06       Impact factor: 3.478

7.  Taenia solium: germinal cell precursors in tapeworms grown in hamster intestine.

Authors:  K Willms; M T Merchant; M Gómez; L Robert
Journal:  Arch Med Res       Date:  2001 Jan-Feb       Impact factor: 2.235

8.  A new approach for the characterization of proliferative cells in cestodes.

Authors:  M F Domínguez; U Koziol; V Porro; A Costábile; S Estrade; J Tort; M Bollati-Fogolin; E Castillo
Journal:  Exp Parasitol       Date:  2014-01-24       Impact factor: 2.011

Review 9.  Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes.

Authors:  A Hemphill; B Stadelmann; S Scholl; J Müller; M Spiliotis; N Müller; B Gottstein; M Siles-Lucas
Journal:  Parasitology       Date:  2009-09-21       Impact factor: 3.234

10.  Transient transfection of Echinococcus multilocularis primary cells and complete in vitro regeneration of metacestode vesicles.

Authors:  Markus Spiliotis; Sabrina Lechner; Dennis Tappe; Carsten Scheller; Georg Krohne; Klaus Brehm
Journal:  Int J Parasitol       Date:  2007-11-21       Impact factor: 3.981

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  1 in total

1.  Identification and culture of proliferative cells in abnormal Taenia solium larvae: Role in the development of racemose neurocysticercosis.

Authors:  Miguel A Orrego; Manuela R Verastegui; Carlos M Vasquez; Uriel Koziol; Juan P Laclette; Hector H Garcia; Theodore E Nash
Journal:  PLoS Negl Trop Dis       Date:  2021-03-22
  1 in total

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