Aga Lewelt1, Kristin J Krosschell2, Gregory J Stoddard3, Cindy Weng3, Mei Xue4, Robin L Marcus5, Eduard Gappmaier5, Louis Viollet6, Barbara A Johnson6, Andrea T White7, Donata Viazzo-Trussell6, Philippe Lopes8, Robert H Lane9, John C Carey10, Kathryn J Swoboda6. 1. Division of Physical Medicine and Rehabilitation, Pediatric Motor Disorders Research Program, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, Utah, 84132, USA. 2. Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. 3. Study Design and Biostatistics Center, University of Utah, Salt Lake City, Utah, USA. 4. Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA. 5. Department of Physical Therapy, University of Utah, Salt Lake City, Utah, USA. 6. Department of Neurology, Pediatric Motor Disorders Research Program, University of Utah School of Medicine, Salt Lake City, Utah, USA. 7. Department of Exercise and Sport Science, University of Utah, College of Health, Salt Lake City, Utah, USA. 8. Neuromuscular Degeneration and Plasticity Laboratory, Institut National de la Santé et de la Recherche Médicale UMR-S 1124, University Paris Descartes, Paris, France. 9. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. 10. Division of Pediatric Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Abstract
INTRODUCTION: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. METHODS: We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. RESULTS: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed. CONCLUSIONS: A 12-week supervised, home-based, 3-day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.
INTRODUCTION: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. METHODS: We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. RESULTS: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed. CONCLUSIONS: A 12-week supervised, home-based, 3-day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.
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