Literature DB >> 25597442

Suppression of antigen presentation by IL-10.

Sharad K Mittal1, Paul A Roche2.   

Abstract

Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function. Published by Elsevier Ltd.

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Year:  2015        PMID： 25597442      PMCID： PMC4444374          DOI： 10.1016/j.coi.2014.12.009

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  48 in total

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Journal:  Cell Death Differ       Date:  2006-05       Impact factor: 15.828

2.  STAT1 regulates MD-2 expression in monocytes of sepsis via miR-30a.

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Journal:  Inflammation       Date:  2014-12       Impact factor: 4.092

3.  A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages.

Authors:  Lally L Y Chan; Benny K W Cheung; James C B Li; Allan S Y Lau
Journal:  J Leukoc Biol       Date:  2010-03-31       Impact factor: 4.962

4.  AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling.

Authors:  Kelly Casey Carroll; Benoit Viollet; Jill Suttles
Journal:  J Leukoc Biol       Date:  2013-07-24       Impact factor: 4.962

5.  Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.

Authors:  Taras T Antoniv; Lionel B Ivashkiv
Journal:  Immunology       Date:  2011-01-24       Impact factor: 7.397

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Authors:  Lina E Tze; Keisuke Horikawa; Heather Domaschenz; Debbie R Howard; Carla M Roots; Robert J Rigby; David A Way; Mari Ohmura-Hoshino; Satoshi Ishido; Christopher E Andoniou; Mariapia A Degli-Esposti; Christopher C Goodnow
Journal:  J Exp Med       Date:  2011-01-10       Impact factor: 14.307

7.  Pathogen-triggered activation of plasmacytoid dendritic cells induces IL-10-producing B cells in response to Staphylococcus aureus.

Authors:  Marijo Parcina; María Auxiliadora Miranda-Garcia; Sibel Durlanik; Saskia Ziegler; Benjamin Over; Philipp Georg; Sandra Foermer; Sandra Ammann; Dina Hilmi; Klaus-Josef Weber; Martin Schiller; Klaus Heeg; Wulf Schneider-Brachert; Friedrich Götz; Isabelle Bekeredjian-Ding
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Review 8.  Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes.

Authors:  Alison J Carey; Chee K Tan; Glen C Ulett
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Authors:  Andrew P Hutchins; Diego Diez; Diego Miranda-Saavedra
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  98 in total

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Review 2.  Dysfunction of antigen processing and presentation by dendritic cells in cancer.

Authors:  Joanna Bandola-Simon; Paul A Roche
Journal:  Mol Immunol       Date:  2018-04-05       Impact factor: 4.407

3.  IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.

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Journal:  J Immunol       Date:  2020-03-13       Impact factor: 5.422

Review 4.  Biological Consequences of MHC-II Expression by Tumor Cells in Cancer.

Authors:  Margaret L Axelrod; Rebecca S Cook; Douglas B Johnson; Justin M Balko
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5.  Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults.

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Journal:  Immunogenetics       Date:  2016-06-10       Impact factor: 2.846

Review 6.  Trial watch: DNA-based vaccines for oncological indications.

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Review 7.  T cell subsets: an integral component in pathogenesis of rheumatic heart disease.

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8.  Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.

Authors:  Claire Gorby; Junel Sotolongo Bellón; Stephan Wilmes; Walid Warda; Elizabeth Pohler; Paul K Fyfe; Adeline Cozzani; Christophe Ferrand; Mark R Walter; Suman Mitra; Jacob Piehler; Ignacio Moraga
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9.  Association of serum interleukin-10, interleukin-17A and transforming growth factor-α levels with human benign and malignant breast diseases.

Authors:  Zhuangwei Lv; Min Liu; Jinghui Shen; Dong Xiang; Yunfeng Ma; Yanhong Ji
Journal:  Exp Ther Med       Date:  2018-04-30       Impact factor: 2.447

Review 10.  Therapeutic cancer vaccines.

Authors:  Cornelis J M Melief; Thorbald van Hall; Ramon Arens; Ferry Ossendorp; Sjoerd H van der Burg
Journal:  J Clin Invest       Date:  2015-07-27       Impact factor: 14.808
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