Literature DB >> 25597010

Multidrug resistance-reversal effects of resin glycosides from Dichondra repens.

Wei-Bin Song1, Wen-Qiong Wang1, Shu-Wei Zhang1, Li-Jiang Xuan2.   

Abstract

Investigation of hydrophobic extract of Dichondra repens (Convolvulaceae) led to the isolation of three new resin glycosides dichondrins A-C (1-3), and three known resin glycosides cus-1, cus-2, and cuse 3. All the isolated resin glycosides with an acyclic core were evaluated for their multidrug resistance reversal activities, and the combined use of these compounds at a concentration of 25μM increased the cytotoxicity of vincristine by 1.03-1.78-fold.
Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  Dichondra repens; Multidrug-resistance (MDR) reversal activity; Resin glycoside acids

Mesh：

Substances：

Year:  2015        PMID： 25597010     DOI： 10.1016/j.bmcl.2014.12.083

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Dichondra repens J.R.Forst. and G.Forst.: A Review of Its Traditional Uses, Chemistry, Pharmacology, Toxicology and Applications.

Authors:  Qi Yao; Ying Wang; Zhiyu Dong; Chencen Lai; Botao Chang; Qiuju Gong; Shuaijun Ren; Dongxue Sun; Jie Lu; Ying Gao
Journal:  Front Pharmacol       Date:  2021-02-08       Impact factor: 5.810

2.  Illuminating the lineage-specific diversification of resin glycoside acylsugars in the morning glory (Convolvulaceae) family using computational metabolomics.

Authors:  Lars H Kruse; Alexandra A Bennett; Elizabeth H Mahood; Elena Lazarus; Se Jin Park; Frank Schroeder; Gaurav D Moghe
Journal:  Hortic Res       Date:  2022-01-18       Impact factor: 6.793
  2 in total

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