INTRODUCTION: The pattern of bleeding tendencies in dengue and its corellation with platelet count and other factors requires clarification. METHODOLOGY: A retrospective study on bleeding tendencies in adults with dengue and platelet counts of less than 100,000 per mm(3) was conducted. Factors associated with bleeding were analyzed. The study cohort were grouped as dengue with severe thrombocytopenia when platelet count was < 50,000/mm(3) and as dengue with moderate thrombocytopenia if platelet count was 50,000-100,000/mm(3) RESULTS: A total of 638 patients formed the study cohort. A 24.1% prevalence of bleeding tendencies was observed. Prior anti-platelet drug intake, platelet count of < 70,000/mm(3), international normalized ratio > 2.0, and partial thromboplastin time > 60 seconds were associated with bleeding. Esophagogastroduodenoscopy was found to identify structural gastroduodenal lesions when dengue was complicated by hematemesis or melena. CONCLUSIONS: The results of this study suggest that bleeding complications in dengue can occur at platelet counts of up to 70,000/mm(3), and that prior anti-platelet drug intake increases bleeding risk. Evaluation of hematemesis or melena in dengue with esophagogastroduodenoscopy is beneficial.
INTRODUCTION: The pattern of bleeding tendencies in dengue and its corellation with platelet count and other factors requires clarification. METHODOLOGY: A retrospective study on bleeding tendencies in adults with dengue and platelet counts of less than 100,000 per mm(3) was conducted. Factors associated with bleeding were analyzed. The study cohort were grouped as dengue with severe thrombocytopenia when platelet count was < 50,000/mm(3) and as dengue with moderate thrombocytopenia if platelet count was 50,000-100,000/mm(3) RESULTS: A total of 638 patients formed the study cohort. A 24.1% prevalence of bleeding tendencies was observed. Prior anti-platelet drug intake, platelet count of < 70,000/mm(3), international normalized ratio > 2.0, and partial thromboplastin time > 60 seconds were associated with bleeding. Esophagogastroduodenoscopy was found to identify structural gastroduodenal lesions when dengue was complicated by hematemesis or melena. CONCLUSIONS: The results of this study suggest that bleeding complications in dengue can occur at platelet counts of up to 70,000/mm(3), and that prior anti-platelet drug intake increases bleeding risk. Evaluation of hematemesis or melena in dengue with esophagogastroduodenoscopy is beneficial.
Authors: Elsa M Rojas; Víctor M Herrera; María C Miranda; Diana Patricia Rojas; Adriana M Gómez; Christian Pallares; Sara M Cobos; Lissethe Pardo; Margarita Gélvez; Andrés Páez; Julio C Mantilla; Anilza Bonelo; Edgar Parra; Luis A Villar Journal: Am J Trop Med Hyg Date: 2019-02 Impact factor: 2.345
Authors: Devendra T Mourya; Rajlakshmi Viswanathan; Santosh Kumar Jadhav; Pragya D Yadav; Atanu Basu; Mandeep S Chadha Journal: Indian J Med Res Date: 2017-05 Impact factor: 2.375
Authors: Benigno A M Rocha; Adriana O Guilarde; Angela F L T Argolo; Marianna Peres Tassara; Lucimeire A da Silveira; Isabela C Junqueira; Marília D Turchi; Valéria C R Féres; Celina M T Martelli Journal: Infect Dis Poverty Date: 2017-08-02 Impact factor: 4.520