Literature DB >> 25596457

Chimeric hepatitis B virus (HBV)/hepatitis C virus (HCV) subviral envelope particles induce efficient anti-HCV antibody production in animals pre-immunized with HBV vaccine.

Elodie Beaumont1, Philippe Roingeard2.   

Abstract

The development of an effective, affordable prophylactic vaccine against hepatitis C virus (HCV) remains a medical priority. The recently described chimeric HBV-HCV subviral envelope particles could potentially be used for this purpose, as they could be produced by industrial procedures adapted from those established for the hepatitis B virus (HBV) vaccine. We show here, in an animal model, that pre-existing immunity acquired through HBV vaccination does not influence the immunogenicity of the HCV E2 protein presented by these chimeric particles. Thus, these chimeric HBV-HCV subviral envelope particles could potentially be used as a booster in individuals previously vaccinated against HBV, to induce protective immunity to HCV.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Immune response; Liver diseases; Preventive vaccination; Subviral envelope particles; Viral hepatitis

Mesh:

Substances:

Year:  2015        PMID: 25596457      PMCID: PMC5666088          DOI: 10.1016/j.vaccine.2015.01.007

Source DB:  PubMed          Journal:  Vaccine        ISSN: 0264-410X            Impact factor:   3.641


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