| Literature DB >> 25596457 |
Elodie Beaumont1, Philippe Roingeard2.
Abstract
The development of an effective, affordable prophylactic vaccine against hepatitis C virus (HCV) remains a medical priority. The recently described chimeric HBV-HCV subviral envelope particles could potentially be used for this purpose, as they could be produced by industrial procedures adapted from those established for the hepatitis B virus (HBV) vaccine. We show here, in an animal model, that pre-existing immunity acquired through HBV vaccination does not influence the immunogenicity of the HCV E2 protein presented by these chimeric particles. Thus, these chimeric HBV-HCV subviral envelope particles could potentially be used as a booster in individuals previously vaccinated against HBV, to induce protective immunity to HCV.Entities:
Keywords: Immune response; Liver diseases; Preventive vaccination; Subviral envelope particles; Viral hepatitis
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Year: 2015 PMID: 25596457 PMCID: PMC5666088 DOI: 10.1016/j.vaccine.2015.01.007
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641