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Literature DB >> 25596080

Aberrant promoter hypermethylation of p16 gene in endometrial carcinoma.

Zhuo-ying Hu¹, Liang-dan Tang, Qin Zhou, Lin Xiao, Yi Cao.

Abstract

Previous studies demonstrated that the loss of function of the p16INK4A gene is mainly caused by the hypermethylation of p16 gene promoter; however, whether or not it is associated with the incidence of endometrial carcinoma (EC) remains unclear. In the current study, we conducted a meta-analysis to investigate the effects of p16 gene promoter hypermethylation on the incidence of EC. Detailed research publications were searched from Embase, PubMed, and ISI Web of Knowledge for composition in English or Chinese. The pooled data were collected and analyzed by Review Manager 5.2. Odds ratios (ORs) were calculated and summarized respectively. Six eligible studies, including 261 patients were selected and analyzed. The pooled OR was 0.42, test for overall effect, Z = 10.19, P < 0.0001, indicating that p16 gene promoter hypermethylation was significantly correlated with the EC patients. The results of our study strongly suggest that p16 gene promoter hypermethylation is correlated with an increased risk of EC. P16 gene promoter hypermethylation plays a critical role in endometrial carcinogenesis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 25596080 DOI： 10.1007/s13277-014-2632-3

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

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1. Reprint--preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

Authors: David Moher; Alessandro Liberati; Jennifer Tetzlaff; Douglas G Altman
Journal: Phys Ther Date: 2009-09

2. Low frequency of BRAF and CDKN2A mutations in endometrial cancer.

Authors: Helga B Salvesen; Rajiv Kumar; Ingunn Stefansson; Sabrina Angelini; Nicola MacDonald; Johanna Smeds; Ian J Jacobs; Kari Hemminki; Soma Das; Lars A Akslen
Journal: Int J Cancer Date: 2005-07-20 Impact factor: 7.396

3. Epigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization.

Authors: Marina Di Domenico; Angela Santoro; Carmela Ricciardi; Mirella Iaccarino; Stefania Iaccarino; Mariagrazia Freda; Antonia Feola; Francesca Sanguedolce; Simona Losito; Daniela Pasquali; Attilio Di Spiezio Sardo; Giuseppe Bifulco; Carmine Nappi; Pantaleo Bufo; Maurizio Guida; Gaetano De Rosa; Alberto Abbruzzese; Michele Caraglia; Giuseppe Pannone
Journal: Cancer Biol Ther Date: 2011-09-01 Impact factor: 4.742

4. The Cochrane Collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care.

Authors: L Bero; D Rennie
Journal: JAMA Date: 1995-12-27 Impact factor: 56.272

5. [Correlations of CpG island methylator phenotype and OPCML gene methylation to carcinogenesis of hepatocellular carcinoma].

Authors: Wen-Ji Liu; Li Wang; Jian-Ping Wang; Jin-Qing Li; Chang-Qin Zhang; Lie Zheng; Yun-Fei Yuan
Journal: Ai Zheng Date: 2006-06

6. Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer.

Authors: Kouji Banno; Megumi Yanokura; Nobuyuki Susumu; Makiko Kawaguchi; Nobumaru Hirao; Akira Hirasawa; Katsumi Tsukazaki; Daisuke Aoki
Journal: Oncol Rep Date: 2006-12 Impact factor: 3.906

7. Aberrant DNA hypermethylation of hMLH-1 and CDKN2A/p16 genes in benign, premalignant and malignant endometrial lesions.

Authors: M Guida; F Sanguedolce; P Bufo; A Di Spiezio Sardo; G Bifulco; C Nappi; G Pannone
Journal: Eur J Gynaecol Oncol Date: 2009 Impact factor: 0.196

8. The association between metabolic abnormality and endometrial cancer: a large case-control study in China.

Authors: Yan Zhang; Zhiwei Liu; Xinchun Yu; Xiaofei Zhang; Shiming Lü; Xiaoduan Chen; Bingjian Lü
Journal: Gynecol Oncol Date: 2010-01-22 Impact factor: 5.482

9. OSAT: a tool for sample-to-batch allocations in genomics experiments.

Authors: Li Yan; Changxing Ma; Dan Wang; Qiang Hu; Maochun Qin; Jeffrey M Conroy; Lara E Sucheston; Christine B Ambrosone; Candace S Johnson; Jianmin Wang; Song Liu
Journal: BMC Genomics Date: 2012-12-10 Impact factor: 3.969

Review 10. Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison.

Authors: Gláucia F Cota; Marcos R de Sousa; Tatiani Oliveira Fereguetti; Ana Rabello
Journal: PLoS Negl Trop Dis Date: 2013-05-02

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Authors: Li Su; Hanwei Wang; Jingwei Miao; Ying Liang
Journal: Sci Rep Date: 2015-08-18 Impact factor: 4.379

3. Association between P16INK4a Promoter Methylation and Ovarian Cancer: A Meta-Analysis of 12 Published Studies.

Authors: Xiyue Xiao; Fucheng Cai; Xun Niu; Hao Shi; Yi Zhong
Journal: PLoS One Date: 2016-09-20 Impact factor: 3.240

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Review 5. Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses.

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