Motoshi Hattori1, Mayumi Sako2, Tetsuji Kaneko3, Akira Ashida4, Akira Matsunaga5, Tohru Igarashi6, Noritomo Itami7, Toshiyuki Ohta8, Yoshimitsu Gotoh9, Kenichi Satomura10, Masataka Honda11, Takashi Igarashi12. 1. Department of Pediatric Nephrology, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. hattori@kc.twmu.ac.jp. 2. Division for Clinical Trials, Department of Development Strategy, Center for Social and Clinical Research, National Center for Child Health and Development, Tokyo, Japan. 3. Division of Clinical Research Support Center, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. 4. Department of Pediatrics, Osaka Medical College, Osaka, Japan. 5. Matsunaga Kids Clinic, Yamagata, Japan. 6. Department of Pediatrics, Nippon Medical University, Tokyo, Japan. 7. Kidney Center, Nikko Memorial Hospital, Hokkaido, Japan. 8. Department of Pediatric Nephrology, Hiroshima Prefectural Hospital, Hiroshima, Japan. 9. Department of Pediatrics, Nagoya Daini Red Cross Hospital, Aichi, Japan. 10. Department of Pediatric Nephrology and Metabolism, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan. 11. Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. 12. National Center for Child Health and Development, Tokyo, Japan.
Abstract
BACKGROUND: End-stage renal disease (ESRD) in children is considered a rare, but serious condition. Epidemiological and demographic information on pediatric ESRD patients around the world is important to better understand this disease and to improve patient care. The Japanese Society for Pediatric Nephrology (JSPN) reported epidemiological and demographic data in 1998. Since then, however, there has been no nationwide survey on Japanese children with ESRD. METHODS: The JSPN conducted a cross-sectional nationwide survey in 2012 to update information on the incidence, primary renal disease, initial treatment modalities, and survival in pediatric Japanese patients with ESRD aged less than 20 years during the period 2006-2011. RESULTS: The average incidence of ESRD was 4.0 per million age-related population. Congenital anomalies of the kidney and urinary tract were the most common cause of ESRD, present in 39.8 % of these patients. In addition, 12.2 % had focal segmental glomerulosclerosis and 5.9 % had glomerulonephritis. Initial treatment modalities in patients who commenced renal replacement therapy (RRT) consisted of peritoneal dialysis, hemodialysis, and pre-emptive transplantation (Tx) in 61.7, 16.0, and 22.3 %, respectively. The Japanese RRT mortality rate was 18.2 deaths per 1000 person-years of observation. CONCLUSION: The incidence of ESRD is lower in Japanese children than in children of other high-income countries. Since 1998, notably, there has been a marked increase in pre-emptive Tx as an initial treatment modality for Japanese children with ESRD.
BACKGROUND: End-stage renal disease (ESRD) in children is considered a rare, but serious condition. Epidemiological and demographic information on pediatric ESRDpatients around the world is important to better understand this disease and to improve patient care. The Japanese Society for Pediatric Nephrology (JSPN) reported epidemiological and demographic data in 1998. Since then, however, there has been no nationwide survey on Japanese children with ESRD. METHODS: The JSPN conducted a cross-sectional nationwide survey in 2012 to update information on the incidence, primary renal disease, initial treatment modalities, and survival in pediatric Japanese patients with ESRD aged less than 20 years during the period 2006-2011. RESULTS: The average incidence of ESRD was 4.0 per million age-related population. Congenital anomalies of the kidney and urinary tract were the most common cause of ESRD, present in 39.8 % of these patients. In addition, 12.2 % had focal segmental glomerulosclerosis and 5.9 % had glomerulonephritis. Initial treatment modalities in patients who commenced renal replacement therapy (RRT) consisted of peritoneal dialysis, hemodialysis, and pre-emptive transplantation (Tx) in 61.7, 16.0, and 22.3 %, respectively. The Japanese RRT mortality rate was 18.2 deaths per 1000 person-years of observation. CONCLUSION: The incidence of ESRD is lower in Japanese children than in children of other high-income countries. Since 1998, notably, there has been a marked increase in pre-emptive Tx as an initial treatment modality for Japanese children with ESRD.
Authors: Sharon P Andreoli; Eileen D Brewer; Sandra Watkins; Barbara Fivush; Neil Powe; Jennifer Shevchek; John Foreman Journal: J Am Soc Nephrol Date: 2005-06-29 Impact factor: 10.121
Authors: Nikki J Schoenmaker; Wilma F Tromp; Johanna H van der Lee; Martin Offringa; Jonathan C Craig; Jaap W Groothoff Journal: Nephrol Dial Transplant Date: 2013-10-03 Impact factor: 5.992
Authors: Dagmara Borzych; Lesley Rees; Il Soo Ha; Annabelle Chua; Patricia G Valles; Maria Lipka; Pedro Zambrano; Thurid Ahlenstiel; Sevcan A Bakkaloglu; Ana P Spizzirri; Laura Lopez; Fatih Ozaltin; Nikoleta Printza; Pankaj Hari; Günter Klaus; Mustafa Bak; Andrea Vogel; Gema Ariceta; Hui Kim Yap; Bradley A Warady; Franz Schaefer Journal: Kidney Int Date: 2010-09-01 Impact factor: 10.612
Authors: Bert J van der Heijden; Paul C W van Dijk; Kate Verrier-Jones; Kitty J Jager; J Douglas Briggs Journal: Pediatr Nephrol Date: 2003-12-18 Impact factor: 3.714
Authors: Kariljn J van Stralen; Dagmara Borzych-Dużalka; Hiroshi Hataya; Sean E Kennedy; Kitty J Jager; Enrico Verrina; Carol Inward; Kai Rönnholm; Karel Vondrak; Bradley A Warady; Aleksandra M Zurowska; Franz Schaefer; Pierre Cochat Journal: Kidney Int Date: 2014-02-05 Impact factor: 10.612