| Literature DB >> 25595254 |
Izabela Guimarães Barbosa1, David Henrique Rodrigues2, Natália Pessoa Rocha3, Larissa Fonseca da Cunha Sousa3, Erica Leandro M Vieira3, Ana Cristina Simões-E-Silva4, Arthur Kummer5, Antônio Lúcio Teixeira6.
Abstract
The pathogenesis of autism spectrum disorder (ASD) is unknown, and the immune system has been appointed to play an important role. The interleukin 33 (IL-33), a member of the IL-1, may act as an alarmin. This study aimed to evaluate plasma levels of IL-33, sST2, and IL-1β in 30 patients with ASD in comparison with 18 controls matched by gender, age and maternal age at childbirth. Patients did not differ from controls in IL-33, sST2, and IL-1β plasma levels. Alarmin levels were not correlated with age, and neither was influenced by clinical parameters. Our results undermine the role of IL-33/ST2 in ASD.Entities:
Keywords: Autism; Cytokines; IL-1β; IL-33; sST2
Mesh：
Substances：
Year: 2014 PMID： 25595254 DOI： 10.1016/j.jneuroim.2014.11.021
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478