OBJECTIVE: To examine the role of first-trimester uterine artery Doppler, serum β-hCG and pregnancy-associated placental protein-A (PAPP-A) in prediction of preeclampsia and IUGR. METHODS: A total of 100 pregnant women in the 11-14 weeks' gestation were examined using uterine artery Doppler, serum β-hCG and PAPP-A. All women were followed-up for development of preeclampsia or IUGR. RESULTS: A total of 94 women completed the study of which 7 (7.4%) developed complications. Uterine artery PI and RI were significantly higher whereas serum β-hCG and PAPP-A levels were significantly reduced in patients who developed complications when compared with those who did not. Uterine artery PI had the highest sensitivity (100%) but a low specificity (56% and 45%) in prediction of preeclampsia and IUGR, respectively. Adding PAPP-A to uterine artery PI elevated the specificity into 94.44% and 95.51%, respectively. Combined PI and β-hCG elevated the specificity into 88.89% and 89.89%, respectively. CONCLUSION: Our study suggests that first-trimester uterine artery impedance, as measured by Doppler ultrasound as well as low serum biomarkers (β-hCG and PAPP-A) can be used for prediction of preeclampsia and IUGR. The most sensitive is uterine artery PI. Adding β-hCG to PI improves specificity in prediction of both preeclampsia and IUGR. Uterine artery PI plus PAPP-A is the best combination for prediction of both preeclampsia and IUGR.
OBJECTIVE: To examine the role of first-trimester uterine artery Doppler, serum β-hCG and pregnancy-associated placental protein-A (PAPP-A) in prediction of preeclampsia and IUGR. METHODS: A total of 100 pregnant women in the 11-14 weeks' gestation were examined using uterine artery Doppler, serum β-hCG and PAPP-A. All women were followed-up for development of preeclampsia or IUGR. RESULTS: A total of 94 women completed the study of which 7 (7.4%) developed complications. Uterine artery PI and RI were significantly higher whereas serum β-hCG and PAPP-A levels were significantly reduced in patients who developed complications when compared with those who did not. Uterine artery PI had the highest sensitivity (100%) but a low specificity (56% and 45%) in prediction of preeclampsia and IUGR, respectively. Adding PAPP-A to uterine artery PI elevated the specificity into 94.44% and 95.51%, respectively. Combined PI and β-hCG elevated the specificity into 88.89% and 89.89%, respectively. CONCLUSION: Our study suggests that first-trimester uterine artery impedance, as measured by Doppler ultrasound as well as low serum biomarkers (β-hCG and PAPP-A) can be used for prediction of preeclampsia and IUGR. The most sensitive is uterine artery PI. Adding β-hCG to PI improves specificity in prediction of both preeclampsia and IUGR. Uterine artery PI plus PAPP-A is the best combination for prediction of both preeclampsia and IUGR.
Authors: Hanaa K B Motawea; Maqsood A Chotani; Mehboob Ali; William Ackerman; Guomao Zhao; Amany A E Ahmed; Catalin S Buhimschi; Irina A Buhimschi Journal: Am J Pathol Date: 2018-09-29 Impact factor: 4.307
Authors: Mirjana Barjaktarovic; Tim I M Korevaar; Vincent W V Jaddoe; Yolanda B de Rijke; Theo J Visser; Robin P Peeters; Eric A P Steegers Journal: Eur J Epidemiol Date: 2016-10-05 Impact factor: 8.082
Authors: Vesna Livrinova; Igor Petrov; Igor Samardziski; Viktorija Jovanovska; Aleksandra Atanasova Boshku; Irena Todorovska; Drage Dabeski; Ajla Shabani Journal: Open Access Maced J Med Sci Date: 2019-05-14
Authors: M Barjaktarovic; T I M Korevaar; V W V Jaddoe; Y B de Rijke; R P Peeters; E A P Steegers Journal: Ultrasound Obstet Gynecol Date: 2019-10 Impact factor: 7.299