Shuo Peng1, Elodie Boudes1, Xianming Tan2, Christine Saint-Martin3, Michael Shevell4, Pia Wintermark1. 1. Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada. 2. Biostatistics Core Facility, Research Institute, McGill University Health Centre, Montreal, Canada. 3. Department of Radiology, Montreal Children's Hospital, McGill University, Montreal, Canada. 4. Division of Pediatric Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada.
Abstract
OBJECTIVE: The aim of this article is to assess whether near-infrared spectroscopy (NIRS) identifies, during hypothermia treatment, the asphyxiated newborns who later develop brain injury. STUDY DESIGN: In this study, asphyxiated newborns, for whom later brain injury was defined by brain imaging and/or autopsy results, were monitored by NIRS during therapeutic hypothermia. We compared regional cerebral oxygenation saturation (rSO2) measured by NIRS at key time points for newborns who developed or did not develop later brain injury. RESULTS: A total of 18 asphyxiated newborns treated with hypothermia were enrolled. rSO2 was higher in the asphyxiated newborns who developed later brain injury. Sensitivity within the first 10 hours of hypothermia treatment for an adverse outcome was 100% (95% confidence interval [CI], 70-100%) and specificity was 83% (95% CI, 36-99%). CONCLUSIONS: NIRS appears to identify asphyxiated newborns at risk of developing brain injury as early as the first 10 hours of hypothermia treatment. Thus, NIRS may have an important role as an early outcome predictor in this population. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: The aim of this article is to assess whether near-infrared spectroscopy (NIRS) identifies, during hypothermia treatment, the asphyxiated newborns who later develop brain injury. STUDY DESIGN: In this study, asphyxiated newborns, for whom later brain injury was defined by brain imaging and/or autopsy results, were monitored by NIRS during therapeutic hypothermia. We compared regional cerebral oxygenation saturation (rSO2) measured by NIRS at key time points for newborns who developed or did not develop later brain injury. RESULTS: A total of 18 asphyxiated newborns treated with hypothermia were enrolled. rSO2 was higher in the asphyxiated newborns who developed later brain injury. Sensitivity within the first 10 hours of hypothermia treatment for an adverse outcome was 100% (95% confidence interval [CI], 70-100%) and specificity was 83% (95% CI, 36-99%). CONCLUSIONS: NIRS appears to identify asphyxiated newborns at risk of developing brain injury as early as the first 10 hours of hypothermia treatment. Thus, NIRS may have an important role as an early outcome predictor in this population. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: L Chalak; L Hellstrom-Westas; S Bonifacio; T Tsuchida; V Chock; M El-Dib; An N Massaro; A Garcia-Alix Journal: Semin Fetal Neonatal Med Date: 2021-07-28 Impact factor: 3.726
Authors: Liesbeth Thewissen; Gunnar Naulaers; Dries Hendrikx; Alexander Caicedo; Keith Barrington; Geraldine Boylan; Po-Yin Cheung; David Corcoran; Afif El-Khuffash; Aisling Garvey; Jozef Macko; Neil Marlow; Jan Miletin; Colm P F O'Donnell; John M O'Toole; Zbyněk Straňák; David Van Laere; Hana Wiedermannova; Eugene Dempsey Journal: Pediatr Res Date: 2021-04-20 Impact factor: 3.756