| Literature DB >> 25594183 |
Daniel L Worthley1, Michael Churchill2, Jocelyn T Compton3, Yagnesh Tailor2, Meenakshi Rao4, Yiling Si2, Daniel Levin5, Matthew G Schwartz6, Aysu Uygur6, Yoku Hayakawa2, Stefanie Gross7, Bernhard W Renz2, Wanda Setlik8, Ashley N Martinez3, Xiaowei Chen2, Saqib Nizami3, Heon Goo Lee3, H Paco Kang3, Jon-Michael Caldwell3, Samuel Asfaha2, C Benedikt Westphalen9, Trevor Graham10, Guangchun Jin2, Karan Nagar2, Hongshan Wang2, Mazen A Kheirbek11, Alka Kolhe2, Jared Carpenter2, Mark Glaire2, Abhinav Nair2, Simon Renders2, Nicholas Manieri12, Sureshkumar Muthupalani13, James G Fox13, Maximilian Reichert14, Andrew S Giraud15, Robert F Schwabe2, Jean-Phillipe Pradere16, Katherine Walton17, Ajay Prakash17, Deborah Gumucio17, Anil K Rustgi14, Thaddeus S Stappenbeck12, Richard A Friedman18, Michael D Gershon8, Peter Sims19, Tracy Grikscheit5, Francis Y Lee3, Gerard Karsenty7, Siddhartha Mukherjee20, Timothy C Wang21.
Abstract
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes. OCR stem cells are concentrated within the metaphysis of long bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fracture repair. Grem1 expression also identifies intestinal reticular stem cells (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs).Entities:
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Year: 2015 PMID： 25594183 PMCID： PMC4436082 DOI： 10.1016/j.cell.2014.11.042
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582