Literature DB >> 25593691

Obesity and Women's Health.

A Templeton.   

Abstract

Entities:  

Year:  2014        PMID: 25593691      PMCID: PMC4286855     

Source DB:  PubMed          Journal:  Facts Views Vis Obgyn        ISSN: 2032-0418


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In the last half century obesity has become an epidemic within the developed world, where it is estimated that over 1.5 billion adults are overweight. Nearly 300 million women are now thought to be clinically obese. Being too fat (adiposity) causes significant health problems not only for individuals but also for families and communities who have to bear the cost of managing the associated medical conditions, often utilising a major portion of the total health budget (WHO, 2014). Adiposity has particular consequences for women and for reproductive health. Obesity in women is associated with alterations in the reproductive cycle with a reduction in fertility, as well as an increased risk of polycystic ovarian syndrome (PCOS) and infrequent or no ovulation. Overweight women with PCOS have a tendency towards insulin resistance and are prone to developing diabetes, particularly in later life. All these issues make the treatment of infertility more complicated and less successful (Sam, 2007). Furthermore the tendency toward menstrual and ovarian disturbances associated with obesity may predispose to an increased risk of ovarian, breast and endometrial cancer. In fact it is now clear the incidence of all gynaecological cancer increases with increasing BMI (Bhaskaran et al., 2014). Maternal obesity during pregnancy is also fraught with risks to both the mother and baby. Adverse maternal outcomes associated with obesity include an increased risk of spontaneous miscarriage, gestational diabetes, hypertensive disease of pregnancy including gestational proteinuric hypertension with multi-system consequences (Guelinckx et al., 2008). Pregnancy is more likely to be prolonged, while labour is more likely to be difficult requiring operative delivery which brings increased risk of infection, thrombo-embolism, and debilitation (Aviram et al., 2011). Adverse foetal outcomes associated with maternal adiposity include problems arising from iatrogenic prematurity, macrosomia (big babies) and associated birth trauma especially resulting from shoulder dystocia. Big babies have themselves a predisposition to adiposity and metabolic disorders in childhood and later life. Maternal obesity also confers an elevated risk of congenital abnormalities, particularly congenital heart disease and neural tube defects. The obese woman is also less likely to succeed in breastfeeding, requiring resort to artificial feeding which in itself increases the risk of childhood obesity. Thus maternal obesity has been shown to have significant short and long term consequences for both mother and child and it is now clear that timely lifestyle interventions introduced before becoming pregnant and maintained throughout pregnancy may help to mitigate complications in both. By improving the intrauterine nutritional milieu of the developing foetus, it may be possible to improve the child’s general health and thereby reduce the risk in later life of health problems associated with obesity, including circulatory and respiratory disease as well as mental health (O’Reilly and Reynolds, 2013). EBCOG therefore supports any public health intervention that addresses this emerging public health issue and particularly those measures aimed at education and prevention. The obstetrician is very well placed in the health service structure to contribute. All providers of maternity care and women’s health services should have advice available for all women and particularly those planning pregnancy. Lifestyle advice, particularly on dietary habits and physical activity, should be available particularly to all overweight and obese women. The importance of these issues for the health of the next generation needs particular emphasis.
  5 in total

1.  Obesity and Polycystic Ovary Syndrome.

Authors:  Susan Sam
Journal:  Obes Manag       Date:  2007-04

Review 2.  Maternal obesity: implications for pregnancy outcome and long-term risks-a link to maternal nutrition.

Authors:  Amir Aviram; Moshe Hod; Yariv Yogev
Journal:  Int J Gynaecol Obstet       Date:  2011-11       Impact factor: 3.561

Review 3.  The risk of maternal obesity to the long-term health of the offspring.

Authors:  James R O'Reilly; Rebecca M Reynolds
Journal:  Clin Endocrinol (Oxf)       Date:  2013-01       Impact factor: 3.478

Review 4.  Maternal obesity: pregnancy complications, gestational weight gain and nutrition.

Authors:  I Guelinckx; R Devlieger; K Beckers; G Vansant
Journal:  Obes Rev       Date:  2008-01-21       Impact factor: 9.213

5.  Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults.

Authors:  Krishnan Bhaskaran; Ian Douglas; Harriet Forbes; Isabel dos-Santos-Silva; David A Leon; Liam Smeeth
Journal:  Lancet       Date:  2014-08-13       Impact factor: 79.321

  5 in total
  5 in total

1.  Obesity-related vascular dysfunction persists after weight loss and is associated with decreased vascular glucagon-like peptide receptor in female rats.

Authors:  Risa Kiernan; Dhandevi Persand; Nicole Maddie; Weikang Cai; Maria Alicia Carrillo-Sepulveda
Journal:  Am J Physiol Heart Circ Physiol       Date:  2022-06-24       Impact factor: 5.125

2.  Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome.

Authors:  Yeongseon Ahn; Hyejin Lee; Yoon Shin Cho
Journal:  Diabetes Metab Syndr Obes       Date:  2020-11-12       Impact factor: 3.168

3.  Association of ADIPOQ-rs2241766 and FTO-rs9939609 genetic variants with body mass index trajectory in women of reproductive age over 6 years of follow-up: the PREDI study.

Authors:  Caroline Kroll; Dayana Rodrigues Farias; Thaís Rangel Bousquet Carrilho; Gilberto Kac; Marco Fabio Mastroeni
Journal:  Eur J Clin Nutr       Date:  2021-04-13       Impact factor: 4.016

4.  Relationship of social capital with overweight and obesity among female health care workers.

Authors:  Mojgan Firouzbakht; Mohammad Esmaeil Riahi; Karimollah Hajian-Tilaki; Abbas Ebadi; Aram Tirgar; Maryam Nikpour
Journal:  Caspian J Intern Med       Date:  2019

5.  Obstetrician-Gynecologists' Strategies for Patient Initiation and Maintenance of Antiobesity Treatment with Glucagon-Like Peptide-1 Receptor Agonists.

Authors:  Lisa Gill; Suzanne Mackey
Journal:  J Womens Health (Larchmt)       Date:  2021-02-24       Impact factor: 2.681

  5 in total

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