Literature DB >> 2559368

Increased responsiveness of the cerebral cortical phosphatidylinositol system to noradrenaline and carbachol in senescent rats.

I Nalepa1, A Pintor, S Fortuna, J Vetulani, H Michalek.   

Abstract

The responsiveness of cerebral cortical alpha 1-adrenoceptors and cholinergic muscarinic M1 receptors was assessed in young (3 months) and aged (24 months) male Sprague-Dawley rats. The measure of responsiveness was the accumulation of inositol phosphate (IP) formed in [3H]myo-inositol-preloaded cerebral cortical slices in the presence of lithium, following stimulation with various concentrations of noradrenaline (1-300 microM) and carbachol (5-1000 microM). In old rats the maximum response to noradrenaline was higher by 80%, and that to carbachol by 33%, indicating an increased responsiveness of the investigated receptors in senescence.

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Year:  1989        PMID： 2559368     DOI： 10.1016/0304-3940(89)90816-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

1.  Differential responsiveness of metabotropic glutamate receptors coupled to phosphoinositide hydrolysis to agonists in various brain areas of the adult rat.

Authors:  P Lorenzini; G M Bisso; S Fortuna; H Michalek
Journal:  Neurochem Res       Date:  1996-03       Impact factor: 3.996

2.  Age does not alter Protein kinase C isozymes mRNA expression in rat brain.

Authors:  N Narang; F T Crews
Journal:  Neurochem Res       Date:  1995-10       Impact factor: 3.996

3.  Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats.

Authors:  A Pintor; S Fortuna; P Lorenzini; A Pascale; F Battaini; C Avellino; L Malvezzi Campeggi; S Salvati
Journal:  Neurochem Res       Date:  1996-05       Impact factor: 3.996

4.  Age-related alterations in pre-synaptic and receptor-mediated cholinergic functions in rat brain.

Authors:  R L Büyükuysal; I H Ulus; B K Kiran
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

5.  Regulation of phospholipase C activity by calcium ions and guanine nucleotide in the normoxic cat carotid body.

Authors:  R P Strosznajder; M Pokorski
Journal:  Neurochem Res       Date:  2000-05       Impact factor: 3.996

Review 6.  Age-related changes in signal transduction. Implications for neuronal transmission and potential for drug intervention.

Authors:  T Fülöp; I Seres
Journal:  Drugs Aging       Date:  1994-11       Impact factor: 3.923

7.  Effects of excitatory amino acids on inositol phosphate accumulation in slices of the cerebral cortex of young and aged rats.

Authors:  I Nalepa; A Pintor; E Chalecka-Franaszek; S Fortuna; H Michalek; J Vetulani
Journal:  Neurochem Res       Date:  1993-05       Impact factor: 3.996

8.  Carbachol-induced accumulation of inositol phosphates and its modulation by excitatory amino acids in cortical slices of young and aged rats with down-regulation of muscarinic M-1 receptors.

Authors:  A Pintor; S Fortuna; H Michalek
Journal:  Neurochem Res       Date:  1994-10       Impact factor: 3.996

9.  Transient global brain ischemia in young and aged rats: differences in severity and progression, but not localisation, of lesions evaluated by magnetic resonance imaging.

Authors:  R Canese; S Fortuna; P Lorenzini; F Podo; H Michalek
Journal:  MAGMA       Date:  1998-11       Impact factor: 2.310
  9 in total

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