Literature DB >> 25593455

Emerging concepts in liver graft preservation.

Mohamed Bejaoui1, Eirini Pantazi1, Emma Folch-Puy1, Pedro M Baptista1, Agustín García-Gil1, René Adam1, Joan Roselló-Catafau1.   

Abstract

The urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion (MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures (hypothermia at 4 °C, normothermia at 37 °C and subnormothermia at 20 °C-25 °C). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the "state of the art" and future perspectives in static and dynamic liver graft preservation in order to improve graft viability.

Entities:  

Keywords:  Graft washout solutions; Machine perfusion and liver bioengineering; Preservation solutions; Static cold preservation; Suboptimal liver grafts

Mesh：

Substances：

Year:  2015        PMID： 25593455      PMCID： PMC4292271          DOI： 10.3748/wjg.v21.i2.396

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  115 in total

1.  Efficacy and safety of Celsior preservation fluid in liver transplantation: one-year follow up of a prospective, multicenter, non-randomized study.

Authors:  Karim Boudjema; Stéphane Grandadam; Philippe Compagnon; Ephrem Salamé; Philippe Wolf; Christian Ducerf; Patrice Le Treut; Olivier Soubrane; Daniel Cherqui; Catherine Mouchel; Alain Renault; Eric Bellissant
Journal:  Clin Transplant       Date:  2011-04-21       Impact factor: 2.863

2.  Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death.

Authors:  Z A Stewart; A M Cameron; A L Singer; R A Montgomery; D L Segev
Journal:  Am J Transplant       Date:  2008-11-27       Impact factor: 8.086

Review 3.  Hypothermic organ preservation by static storage methods: Current status and a view to the future.

Authors:  Jonathan F McAnulty
Journal:  Cryobiology       Date:  2009-06-16       Impact factor: 2.487

4.  Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation.

Authors:  B G Bruinsma; H Yeh; S Ozer; P N Martins; A Farmer; W Wu; N Saeidi; S Op den Dries; T A Berendsen; R N Smith; J F Markmann; R J Porte; M L Yarmush; K Uygun; M-L Izamis
Journal:  Am J Transplant       Date:  2014-04-23       Impact factor: 8.086

5.  Organ Preservation: Current Concepts and New Strategies for the Next Decade.

Authors:  Edgardo E Guibert; Alexander Y Petrenko; Cecilia L Balaban; Alexander Y Somov; Joaquín V Rodriguez; Barry J Fuller
Journal:  Transfus Med Hemother       Date:  2011-03-21       Impact factor: 3.747

6.  Liver preservation below 0 degrees C with UW solution and 2,3-butanediol.

Authors:  M Scotte; P Eschwege; C Cherruau; F Fontaliran; F Moreau; D Houssin
Journal:  Cryobiology       Date:  1996-02       Impact factor: 2.487

7.  A subset of 26S proteasomes is activated at critically low ATP concentrations and contributes to myocardial injury during cold ischemia.

Authors:  Qing Geng; Jacqueline Romero; Vikas Saini; Todd A Baker; Maria M Picken; Richard L Gamelli; Matthias Majetschak
Journal:  Biochem Biophys Res Commun       Date:  2009-12-25       Impact factor: 3.575

8.  Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo.

Authors:  Deepak Nagrath; Hongzhi Xu; Yoko Tanimura; Rongjun Zuo; François Berthiaume; Marco Avila; Rubin Yarmush; Martin L Yarmush
Journal:  Metab Eng       Date:  2009-06-07       Impact factor: 9.783

9.  IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation.

Authors:  I B Mosbah; M A Zaouali; C Martel; M Bjaoui; H B Abdennebi; G Hotter; C Brenner; J Roselló-Catafau
Journal:  Cell Death Dis       Date:  2012-03-08       Impact factor: 8.469

10.  Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress.

Authors:  Yusuke S Hori; Atsushi Kuno; Ryusuke Hosoda; Yoshiyuki Horio
Journal:  PLoS One       Date:  2013-09-11       Impact factor: 3.240
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  27 in total

Review 1.  Strategies to optimize the use of marginal donors in liver transplantation.

Authors:  Daniele Pezzati; Davide Ghinolfi; Paolo De Simone; Emanuele Balzano; Franco Filipponi
Journal:  World J Hepatol       Date:  2015-11-18

Review 2.  Post reperfusion syndrome during liver transplantation: From pathophysiology to therapy and preventive strategies.

Authors:  Antonio Siniscalchi; Lorenzo Gamberini; Cristiana Laici; Tommaso Bardi; Giorgio Ercolani; Laura Lorenzini; Stefano Faenza
Journal:  World J Gastroenterol       Date:  2016-01-28       Impact factor: 5.742

Review 3.  ICU Management of the Potential Organ Donor: State of the Art.

Authors:  Carolina B Maciel; David M Greer
Journal:  Curr Neurol Neurosci Rep       Date:  2016-09       Impact factor: 5.081

Review 4.  Polyethylene glycols: An effective strategy for limiting liver ischemia reperfusion injury.

Authors:  Gianfranco Pasut; Arnau Panisello; Emma Folch-Puy; Alexandre Lopez; Carlos Castro-Benítez; Maria Calvo; Teresa Carbonell; Agustín García-Gil; René Adam; Joan Roselló-Catafau
Journal:  World J Gastroenterol       Date:  2016-07-28       Impact factor: 5.742

Review 5.  NAFLD and liver transplantation: Current burden and expected challenges.

Authors:  Raluca Pais; A Sidney Barritt; Yvon Calmus; Olivier Scatton; Thomas Runge; Pascal Lebray; Thierry Poynard; Vlad Ratziu; Filomena Conti
Journal:  J Hepatol       Date:  2016-07-30       Impact factor: 25.083

6.  8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation.

Authors:  Qinlong Liu; Hasibur Rehman; Yasodha Krishnasamy; John J Lemasters; Zhi Zhong
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2017-06-15

Review 7.  Organ preservation: from the past to the future.

Authors:  Lei Jing; Leeann Yao; Michael Zhao; Li-Ping Peng; Mingyao Liu
Journal:  Acta Pharmacol Sin       Date:  2018-03-22       Impact factor: 6.150

Review 8.  Peri-transplant management of nonalcoholic fatty liver disease in liver transplant candidates .

Authors:  Naga Swetha Samji; Rajiv Heda; Sanjaya K Satapathy
Journal:  Transl Gastroenterol Hepatol       Date:  2020-01-05

Review 9.  Melatonin role preventing steatohepatitis and improving liver transplantation results.

Authors:  Eduardo Esteban-Zubero; Francisco Agustín García-Gil; Laura López-Pingarrón; Moisés Alejandro Alatorre-Jiménez; José Manuel Ramírez; Dun-Xian Tan; José Joaquín García; Russel J Reiter
Journal:  Cell Mol Life Sci       Date:  2016-03-29       Impact factor: 9.261

Review 10.  Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application.

Authors:  Yury S Tarahovsky; Irina S Fadeeva; Natalia P Komelina; Maxim O Khrenov; Nadezhda M Zakharova
Journal:  Psychopharmacology (Berl)       Date:  2016-12-08       Impact factor: 4.530
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