Literature DB >> 25592835

Hyaluronan inhibits BMP-induced osteoblast differentiation.

Keiko Kaneko1, Chikahisa Higuchi1, Yasuo Kunugiza1, Kiyoshi Yoshida1, Takashi Sakai1, Hideki Yoshikawa1, Ken Nakata2.   

Abstract

Hyaluronan (HA), one of the major structural extracellular components in cartilage, regulates cellular responses via receptors such as CD44. However, the direct effects of HA on osteoblastic differentiation has not been studied in detail. Here, we investigated the effects of HA (molecular weight: 900-1200 kDa) on osteoblastic differentiation that was induced by bone morphogenetic protein (BMP) in C2C12 cells (mouse myoblastic cells) and ST2 cells (mouse bone marrow cells). BMP-induced osteoblastic differentiation and Smad1/Smad5/Smad8 phosphorylation were downregulated by HA. Use of the CD44-blocking antibody restored HA-induced inhibition of osteoblastic differentiation and Smad1/Smad5/Smad8 phosphorylation. Our results indicate that HA inhibits BMP-induced osteoblastic differentiation through the CD44 receptor.
Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Bone morphogenetic protein; CD44; Hyaluronan; Osteoblast

Mesh：

Substances：

Year:  2015        PMID： 25592835     DOI： 10.1016/j.febslet.2014.12.031

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

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2.  In vitro effects of hyaluronic acid on human periodontal ligament cells.

Authors:  Masako Fujioka-Kobayashi; Heinz-Dieter Müller; Andrea Mueller; Adrian Lussi; Anton Sculean; Patrick R Schmidlin; Richard J Miron
Journal:  BMC Oral Health       Date:  2017-01-16       Impact factor: 2.757

3.  Effect of cell culture density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation.

Authors:  Sonoko Noda; Nobuyuki Kawashima; Mioko Yamamoto; Kentaro Hashimoto; Keisuke Nara; Ichiro Sekiya; Takashi Okiji
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4.  Fabrication of Low-Molecular-Weight Hyaluronic Acid-Carboxymethyl Cellulose Hybrid to Promote Bone Growth in Guided Bone Regeneration Surgery: An Animal Study.

Authors:  Chun-Yu Lin; Po-Jan Kuo; Ya-Hui Lin; Chi-Yu Lin; Jerry Chin-Yi Lin; Hsien-Chung Chiu; Tsung-Fu Hung; Hung-Yun Lin; Haw-Ming Huang
Journal:  Polymers (Basel)       Date:  2022-08-06       Impact factor: 4.967

5.  Hyaluronidase 1 deficiency decreases bone mineral density in mice.

Authors:  Florentine Gilis; Virginie Tevel; Emeline Puissant; Jean-Michel Vandeweerd; Bruno Flamion; Michel Jadot; Marielle Boonen
Journal:  Sci Rep       Date:  2022-06-16       Impact factor: 4.996

Review 6.  Review of the Mechanism of Action for Supartz FX in Knee Osteoarthritis.

Authors:  Roy D Altman; Vinod Dasa; Jun Takeuchi
Journal:  Cartilage       Date:  2016-12-29       Impact factor: 4.634

7.  Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts.

Authors:  Maria B Asparuhova; Vivianne Chappuis; Alexandra Stähli; Daniel Buser; Anton Sculean
Journal:  Clin Oral Investig       Date:  2020-03-31       Impact factor: 3.573
  7 in total

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