Literature DB >> 25592708

Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages.

Jin Woo Lee1, Ji Hoon Lee1, Chul Lee2, Qinghao Jin1, Dongho Lee3, Youngsoo Kim1, Jin Tae Hong1, Mi Kyeong Lee1, Bang Yeon Hwang4.   

Abstract

Bioactivity-guided fractionation of the MeOH extract from the roots of Sophora tonkinensis resulted in the isolation of a new pterocarpan glycoside (1) together with nine known compounds, maackiain (2), sophoranone (3), sophoranochromene (4), pinoresinol (5), syringaresinol (6), medioresinol (7), 4',7-dihydroxyflavone (8), calycosin (9), and genistein (10). The structure of the new compound was determined on the basis of spectroscopic analysis including NMR and CD data in combination with acid hydrolysis. Compounds 1-4 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 13.6 to 33.0μM in RAW 264.7 macrophages.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Leguminosae; Nitric oxide production inhibitor; Pterocarpan; Sophora tonkinensis

Mesh：

Substances：

Year:  2014        PMID： 25592708     DOI： 10.1016/j.bmcl.2014.12.012

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Biological Activities and Secondary Metabolites from Sophora tonkinensis and Its Endophytic Fungi.

Authors:  Jia-Jun Liang; Pan-Pan Zhang; Wei Zhang; Da Song; Xin Wei; Xin Yin; Yong-Qiang Zhou; Xiang Pu; Ying Zhou
Journal:  Molecules       Date:  2022-08-29       Impact factor: 4.927

2.  Polyphenolic Compounds from Lespedeza bicolor Protect Neuronal Cells from Oxidative Stress.

Authors:  Darya V Tarbeeva; Evgeny A Pislyagin; Ekaterina S Menchinskaya; Dmitrii V Berdyshev; Anatoliy I Kalinovskiy; Valeria P Grigorchuk; Natalia P Mishchenko; Dmitry L Aminin; Sergey A Fedoreyev
Journal:  Antioxidants (Basel)       Date:  2022-04-03

3.  Maackiain Ameliorates 6-Hydroxydopamine and SNCA Pathologies by Modulating the PINK1/Parkin Pathway in Models of Parkinson's Disease in Caenorhabditis elegans and the SH-SY5Y Cell Line.

Authors:  Rong-Tzong Tsai; Chia-Wen Tsai; Shih-Ping Liu; Jia-Xin Gao; Yun-Hua Kuo; Pei-Min Chao; Huey-Shan Hung; Woei-Cherng Shyu; Shinn-Zong Lin; Ru-Huei Fu
Journal:  Int J Mol Sci       Date:  2020-06-23       Impact factor: 5.923

4.  Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone.

Authors:  Yu Fen Zheng; Soo Hyeon Bae; Zhouchi Huang; Soon Uk Chae; Seong Jun Jo; Hyung Joon Shim; Chae Bin Lee; Doyun Kim; Hunseung Yoo; Soo Kyung Bae
Journal:  Pharmaceutics       Date:  2020-04-07       Impact factor: 6.321

5.  Preparative Purification of Total Flavonoids from Sophora tonkinensis Gagnep. by Macroporous Resin Column Chromatography and Comparative Analysis of Flavonoid Profiles by HPLC-PAD.

Authors:  Mengyang Hou; Wenzhong Hu; Zhilong Xiu; Aili Jiang; Lei Men; Kexin Hao; Xingsheng Sun; Duo Cao
Journal:  Molecules       Date:  2019-09-03       Impact factor: 4.411

6.  Four New Iridoid Metabolites Have Been Isolated from the Stems of Neonauclea reticulata (Havil.) Merr. with Anti-Inflammatory Activities on LPS-Induced RAW264.7 Cells.

Authors:  Fang-Pin Chang; Shyh-Shyun Huang; Tzong-Huei Lee; Chi-I Chang; Tzong-Fu Kuo; Guan-Jhong Huang; Yueh-Hsiung Kuo
Journal:  Molecules       Date:  2019-11-23       Impact factor: 4.411

7.  Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. in KK-Ay Mice.

Authors:  Mi Huang; Shihao Deng; Qianqian Han; Ping Zhao; Qi Zhou; Sijian Zheng; Xinhua Ma; Chan Xu; Jing Yang; Xinzhou Yang
Journal:  Front Pharmacol       Date:  2016-09-05       Impact factor: 5.810
  7 in total

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