Neelesh K Nadkarni1, Subashan Perera2, Joseph T Hanlon3, Oscar Lopez4, Anne B Newman5, Howard Aizenstein6, Marshall Elam7, Tamara B Harris8, Stephen Kritchevsky9, Kristine Yaffe10, Caterina Rosano5. 1. Division of Geriatric Medicine and Gerontology - Department of Medicine, University of Pittsburgh - School of Medicine, Pittsburgh, PA, USA. Electronic address: nkn3@pitt.edu. 2. Division of Geriatric Medicine and Gerontology - Department of Medicine, University of Pittsburgh - School of Medicine, Pittsburgh, PA, USA. 3. Division of Geriatric Medicine and Gerontology - Department of Medicine, University of Pittsburgh - School of Medicine, Pittsburgh, PA, USA; Department of Epidemiology - Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 4. Department of Neurology, University of Pittsburgh - School of Medicine, Pittsburgh, PA, USA; University of Pittsburgh Alzheimer's Disease Research Center, Pittsburgh, PA, USA. 5. Department of Epidemiology - Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 6. Department of Psychiatry, University of Pittsburgh - School of Medicine, Pittsburgh, PA, USA. 7. Department of Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA. 8. Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA. 9. Department of Gerontology and Geriatrics, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA. 10. Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA.
Abstract
INTRODUCTION: We examined whether statins are associated with better cerebral white (WM) and gray matter (GM) indices in community-dwelling elders. METHODS: In 295 older adults, we compared white matter hyperintensities (WMH) on brain magnetic resonance imaging and, total WM fractional anisotropy (FA) and GM mean diffusivity (MD) on diffusion tensor imaging, of Alzheimer's disease (AD) relevant regions in statin-exposed and statin-unexposed participants stratified by Modified Mini-Mental Status Examination (3MS) score. RESULTS: There was no overall effect of statin exposure on cerebral structural indices. The interaction between statin exposure and 3MS was significant for total-WMH and WM FA (both P < .05) but not GM MD. In the lowest 3MS tertile (mean: 86), statin-exposed individuals had lower total-WMH and higher WM FA (P = .005 and P = .044) and FA of tracts linked to clinical AD (P-value range= .005-.04) despite statistical adjustments. These differences were not significant in the two higher 3MS tertiles. DISCUSSION: Statins may benefit WM in older adults vulnerable to dementia.
INTRODUCTION: We examined whether statins are associated with better cerebral white (WM) and gray matter (GM) indices in community-dwelling elders. METHODS: In 295 older adults, we compared white matter hyperintensities (WMH) on brain magnetic resonance imaging and, total WM fractional anisotropy (FA) and GM mean diffusivity (MD) on diffusion tensor imaging, of Alzheimer's disease (AD) relevant regions in statin-exposed and statin-unexposed participants stratified by Modified Mini-Mental Status Examination (3MS) score. RESULTS: There was no overall effect of statin exposure on cerebral structural indices. The interaction between statin exposure and 3MS was significant for total-WMH and WM FA (both P < .05) but not GM MD. In the lowest 3MS tertile (mean: 86), statin-exposed individuals had lower total-WMH and higher WM FA (P = .005 and P = .044) and FA of tracts linked to clinical AD (P-value range= .005-.04) despite statistical adjustments. These differences were not significant in the two higher 3MS tertiles. DISCUSSION: Statins may benefit WM in older adults vulnerable to dementia.
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