Sungmin Park1, Min-Gew Choi2, Kyoung-Mee Kim3, Hye Seung Kim4, Sin-Ho Jung4, Jun Ho Lee1, Jae Hyung Noh1, Tae Sung Sohn1, Jae Moon Bae1, Sung Kim1. 1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 2. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address: mingew.choi@samsung.com. 3. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 4. Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract
BACKGROUND: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric carcinoma and has histologic features of intense lymphocytic infiltration. In this study, we attempted to analyze the clinicopathologic characteristics and survival outcome of patients with LELC compared with those with non-lymphoepithelioma-like carcinoma (NLELC). METHODS: We studied 4282 patients who underwent gastrectomies to treat gastric cancer at the Department of Surgery of the Samsung Medical Center in Seoul, between January 2008 and December 2010. The clinicopathologic features and clinical outcomes of patients with LELC (n = 46) were compared with those with NLELC (n = 4236). In situ hybridization for Epstein-Barr virus (EBV) positivity was performed on the tissue of patients with LELC (n = 46) and NLELC (n = 1247). RESULTS: The patients with LELC are male predominant and had more upper locations, more indeterminate Lauren classifications, lower T stages, less lymphatic invasion, and more positive EBV in situ hybridization compared with those of the NLELC group (80.4% versus 6.5%). Age, histologic type, Lauren type, the location of the tumor, the depth of the invasion, lymph node metastasis, and venous invasion were independent prognostic factors; however, the LELC type itself was not predictive of outcome. The 5-y survival rate of the LELC group (97.7%) was better than that of the NLELC group (89.4%); however, this difference was not statistically significant (P = 0.127). CONCLUSIONS: The results of our study suggest that LELC is a less advanced disease than NLELC in terms of depth of invasion and lymphatic invasion at diagnosis. However, our study does not examine LELC as an independent prognostic factor of gastric cancer. Further studies are needed to explore its associations with EBV and a distinct pathway of carcinogenesis from NLELC.
BACKGROUND:Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric carcinoma and has histologic features of intense lymphocytic infiltration. In this study, we attempted to analyze the clinicopathologic characteristics and survival outcome of patients with LELC compared with those with non-lymphoepithelioma-like carcinoma (NLELC). METHODS: We studied 4282 patients who underwent gastrectomies to treat gastric cancer at the Department of Surgery of the Samsung Medical Center in Seoul, between January 2008 and December 2010. The clinicopathologic features and clinical outcomes of patients with LELC (n = 46) were compared with those with NLELC (n = 4236). In situ hybridization for Epstein-Barr virus (EBV) positivity was performed on the tissue of patients with LELC (n = 46) and NLELC (n = 1247). RESULTS: The patients with LELC are male predominant and had more upper locations, more indeterminate Lauren classifications, lower T stages, less lymphatic invasion, and more positive EBV in situ hybridization compared with those of the NLELC group (80.4% versus 6.5%). Age, histologic type, Lauren type, the location of the tumor, the depth of the invasion, lymph node metastasis, and venous invasion were independent prognostic factors; however, the LELC type itself was not predictive of outcome. The 5-y survival rate of the LELC group (97.7%) was better than that of the NLELC group (89.4%); however, this difference was not statistically significant (P = 0.127). CONCLUSIONS: The results of our study suggest that LELC is a less advanced disease than NLELC in terms of depth of invasion and lymphatic invasion at diagnosis. However, our study does not examine LELC as an independent prognostic factor of gastric cancer. Further studies are needed to explore its associations with EBV and a distinct pathway of carcinogenesis from NLELC.
Authors: Namrata Setia; Agoston T Agoston; Hye S Han; John T Mullen; Dan G Duda; Jeffrey W Clark; Vikram Deshpande; Mari Mino-Kenudson; Amitabh Srivastava; Jochen K Lennerz; Theodore S Hong; Eunice L Kwak; Gregory Y Lauwers Journal: Mod Pathol Date: 2016-04-01 Impact factor: 7.842
Authors: Irene Gullo; Patrícia Oliveira; Maria Athelogou; Gilza Gonçalves; Marta L Pinto; Joana Carvalho; Ana Valente; Hugo Pinheiro; Sara Andrade; Gabriela M Almeida; Ralf Huss; Kakoli Das; Patrick Tan; José C Machado; Carla Oliveira; Fátima Carneiro Journal: Gastric Cancer Date: 2018-05-19 Impact factor: 7.370
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