Akiko Shimada1, Lene Baad-Hansen2, Eduardo Castrillon2, Bijar Ghafouri3, Niclas Stensson4, Björn Gerdle4, Malin Ernberg5, Brian Cairns6, Peter Svensson2, Peter Svensson Odont. 1. Section of Clinical Oral Physiology, Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON). Electronic address: akiko.shimada@odontologi.au.dk. 2. Section of Clinical Oral Physiology, Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON). 3. Department of Medical and Health Sciences, Rehabilitation Medicine, Faculty of Health Sciences, Linköping University & Pain and Rehabilitation Centre, County Council of Östergötland, Linköping, Sweden; Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine, Faculty of Health Sciences, Linköping University and Centre of Occupational and Environmental Medicine, County Council of Östergötland, Linköping, Sweden. 4. Department of Medical and Health Sciences, Rehabilitation Medicine, Faculty of Health Sciences, Linköping University & Pain and Rehabilitation Centre, County Council of Östergötland, Linköping, Sweden. 5. Scandinavian Center for Orofacial Neurosciences (SCON); Section of Orofacial Pain and Jaw Function, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. 6. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Abstract
OBJECTIVE: The aim of this study was to determine the relationship of high daily monosodium glutamate (MSG) consumption with glutamate concentrations in jaw muscle, saliva, and serum, and muscle pain sensitivity in healthy participants. METHODS: A randomized, double-blinded, placebo-controlled study was conducted to investigate the effect of repetitive consumption of high-dose MSG on glutamate concentration in the masseter muscles measured by microdialysis and muscle pain sensitivity. In five contiguous experimental daily sessions, 32 healthy participantsdrank MSG (150 mg/kg) or NaCl (24 mg/kg) diluted with a 400 mL soda. The concentrations of glutamate before and after the ingestion were assessed in dialysate and plasma samples on the first and last days. Saliva glutamate concentration was assessed every day. Pressure pain threshold, pressure pain tolerance, autonomic parameters (heart rate, systolic and diastolic blood pressures) and reported side effects also were assessed. RESULTS: No significant change was noted in the baseline concentration of glutamate in the masseter muscle, blood, or saliva, but the peak concentration in the masseter muscle increased significantly between day 1 and 5. A statistically significant increase in systolic and diastolic blood pressures after MSG administration was observed, as well as a significantly higher frequency of reports of nausea and headache in the MSG group. No robust effect of MSG on muscle sensitivity was found. CONCLUSION: Interstitial glutamate concentration in the masseter muscle is not highly disturbed by excessive repetitive intake of MSG in healthy man.
RCT Entities:
OBJECTIVE: The aim of this study was to determine the relationship of high daily monosodium glutamate (MSG) consumption with glutamate concentrations in jaw muscle, saliva, and serum, and muscle pain sensitivity in healthy participants. METHODS: A randomized, double-blinded, placebo-controlled study was conducted to investigate the effect of repetitive consumption of high-dose MSG on glutamate concentration in the masseter muscles measured by microdialysis and muscle pain sensitivity. In five contiguous experimental daily sessions, 32 healthy participants drank MSG (150 mg/kg) or NaCl (24 mg/kg) diluted with a 400 mL soda. The concentrations of glutamate before and after the ingestion were assessed in dialysate and plasma samples on the first and last days. Saliva glutamate concentration was assessed every day. Pressure pain threshold, pressure pain tolerance, autonomic parameters (heart rate, systolic and diastolic blood pressures) and reported side effects also were assessed. RESULTS: No significant change was noted in the baseline concentration of glutamate in the masseter muscle, blood, or saliva, but the peak concentration in the masseter muscle increased significantly between day 1 and 5. A statistically significant increase in systolic and diastolic blood pressures after MSG administration was observed, as well as a significantly higher frequency of reports of nausea and headache in the MSG group. No robust effect of MSG on muscle sensitivity was found. CONCLUSION: Interstitial glutamate concentration in the masseter muscle is not highly disturbed by excessive repetitive intake of MSG in healthy man.
Authors: Anca Zanfirescu; Aurelia Nicoleta Cristea; George Mihai Nitulescu; Bruno Stefan Velescu; Daniela Gradinaru Journal: Nutrients Date: 2017-12-21 Impact factor: 5.717