Literature DB >> 25591453

A surprising role for the Sch9 protein kinase in chromosome segregation in Candida albicans.

Neha Varshney1, Alida Schaekel2, Rima Singha1, Tanmoy Chakraborty1, Lasse van Wijlick2, Joachim F Ernst3, Kaustuv Sanyal4.   

Abstract

The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation.
Copyright © 2015 by the Genetics Society of America.

Entities:  

Keywords:  Sch9; centromere; chromosome segregation; kinase; kinetochore

Mesh：

Substances：

Year:  2015        PMID： 25591453      PMCID： PMC4349062          DOI： 10.1534/genetics.114.173542

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  21 in total

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Journal:  Mol Microbiol       Date:  2011-02-10       Impact factor: 3.501

2.  Regulation of longevity and stress resistance by Sch9 in yeast.

Authors:  P Fabrizio; F Pozza; S D Pletcher; C M Gendron; V D Longo
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

3.  Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore.

Authors:  Vivien Measday; Dale W Hailey; Isabelle Pot; Scott A Givan; Katherine M Hyland; Gerard Cagney; Stan Fields; Trisha N Davis; Philip Hieter
Journal:  Genes Dev       Date:  2002-01-01       Impact factor: 11.361

4.  The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation.

Authors:  S K Ghosh; A Poddar; S Hajra; K Sanyal; P Sinha
Journal:  Mol Genet Genomics       Date:  2001-04       Impact factor: 3.291

5.  Sch9 kinase integrates hypoxia and CO2 sensing to suppress hyphal morphogenesis in Candida albicans.

Authors:  Catrin Stichternoth; Alida Fraund; Eleonora Setiadi; Luc Giasson; Anna Vecchiarelli; Joachim F Ernst
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6.  Polo-like kinase 1 licenses CENP-A deposition at centromeres.

Authors:  Kara L McKinley; Iain M Cheeseman
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7.  Efficient neocentromere formation is suppressed by gene conversion to maintain centromere function at native physical chromosomal loci in Candida albicans.

Authors:  Jitendra Thakur; Kaustuv Sanyal
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8.  A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans.

Authors:  Jitendra Thakur; Kaustuv Sanyal
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9.  Rad51-Rad52 mediated maintenance of centromeric chromatin in Candida albicans.

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Journal:  PLoS Genet       Date:  2014-04-24       Impact factor: 5.917

10.  Morphogenesis-regulated localization of protein kinase A to genomic sites in Candida albicans.

Authors:  Alida Schaekel; Prashant R Desai; Joachim F Ernst
Journal:  BMC Genomics       Date:  2013-12-01       Impact factor: 3.969
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  4 in total

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Authors:  Patrícia Alves de Castro; Thaila Fernanda Dos Reis; Stephen K Dolan; Adriana Oliveira Manfiolli; Neil Andrew Brown; Gary W Jones; Sean Doyle; Diego M Riaño-Pachón; Fábio Márcio Squina; Camila Caldana; Ashutosh Singh; Maurizio Del Poeta; Daisuke Hagiwara; Rafael Silva-Rocha; Gustavo H Goldman
Journal:  Mol Microbiol       Date:  2016-10-07       Impact factor: 3.501

Review 2.  Candida glabrata: new tools and technologies-expanding the toolkit.

Authors:  Hsueh-lui Ho; Ken Haynes
Journal:  FEMS Yeast Res       Date:  2015-07-22       Impact factor: 2.796

3.  Genome engineering in the yeast pathogen Candida glabrata using the CRISPR-Cas9 system.

Authors:  Ludovic Enkler; Delphine Richer; Anthony L Marchand; Dominique Ferrandon; Fabrice Jossinet
Journal:  Sci Rep       Date:  2016-10-21       Impact factor: 4.379

4.  Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres.

Authors:  Krishnendu Guin; Yao Chen; Radha Mishra; Siti Rawaidah Bm Muzaki; Bhagya C Thimmappa; Caoimhe E O'Brien; Geraldine Butler; Amartya Sanyal; Kaustuv Sanyal
Journal:  Elife       Date:  2020-05-29       Impact factor: 8.140
  4 in total

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